CAJ | 학술논문

目的：探讨抑郁对冠心病（CHD ）患者生存质量、运动耐力的影响程度。方法131例CHD患者由本人独立填写完成贝克抑郁自评量表（BDI）和简明健康测量量表（SF_36）。根据BDI评分将患者分为抑郁组（n＝34）、非抑郁组（n＝97）并分别行心肺运动试验（CPET ）。结果（1）131例CHD患者SF_36各维度均低于中国常模，除社会功能外各维度有显著差异（ P＜0.01），抑郁组CHD患者SF_36各维度得分均低于非抑郁组患者，除生理功能、生理职能外各维度有显著差异（ P＜0.05，或 P＜0.01）。（2）抑郁组CHD患者CPET结果中峰值氧耗量（VO2 peak ）、无氧代谢阈值氧耗量（VO2AT）、无氧代谢阈值负荷（LoadAT）均低于非抑郁组，分别为VO2peak：（17.3±1.7）ml·kg-1·min-1比（18.6±2.9）ml· kg-1·min-1，P＜0.05；VO2AT：（12.0±1.7）ml·kg-1·min-1比（13.2±2.2）ml·kg-1·min-1，P＜0.01；LoadAT ：（30.7±11.4）J ·s-1比（36.0±13.9）J·s-1，P＜0.05。（3）CHD患者SF_36与运动耐力有相关性（ P＜0.05）；SF_36各维度得分与BDI评分有显著负相关性（ P＜0.05）；BDI评分与CPET结果中VO2 peak、VO2 AT、LoadAT有显著负相关性（ P＜0.05）。结论合并抑郁的冠心病患者生存质量和运动耐力下降，抑郁与冠心病患者生存质量和运动耐力密切相关。
목적：탐토억욱대관심병（CHD ）환자생존질량、운동내력적영향정도。방법131례CHD환자유본인독립전사완성패극억욱자평량표（BDI）화간명건강측량량표（SF_36）。근거BDI평분장환자분위억욱조（n＝34）、비억욱조（n＝97）병분별행심폐운동시험（CPET ）。결과（1）131례CHD환자SF_36각유도균저우중국상모，제사회공능외각유도유현저차이（ P＜0.01），억욱조CHD환자SF_36각유도득분균저우비억욱조환자，제생리공능、생리직능외각유도유현저차이（ P＜0.05，혹 P＜0.01）。（2）억욱조CHD환자CPET결과중봉치양모량（VO2 peak ）、무양대사역치양모량（VO2AT）、무양대사역치부하（LoadAT）균저우비억욱조，분별위VO2peak：（17.3±1.7）ml·kg-1·min-1비（18.6±2.9）ml· kg-1·min-1，P＜0.05；VO2AT：（12.0±1.7）ml·kg-1·min-1비（13.2±2.2）ml·kg-1·min-1，P＜0.01；LoadAT ：（30.7±11.4）J ·s-1비（36.0±13.9）J·s-1，P＜0.05。（3）CHD환자SF_36여운동내력유상관성（ P＜0.05）；SF_36각유도득분여BDI평분유현저부상관성（ P＜0.05）；BDI평분여CPET결과중VO2 peak、VO2 AT、LoadAT유현저부상관성（ P＜0.05）。결론합병억욱적관심병환자생존질량화운동내력하강，억욱여관심병환자생존질량화운동내력밀절상관。
Objective To explore effects of depression on quality of life and exercise tolerance in patients with coronary heart disease (CHD). Methods 131 patients with CHD completed Beck Depression Inventory (BDI) and the MOS 36_Item Short_From Health sur-vey(SF_36)independently.According to the scores of BDI ,the patients were divided into depression group (n=34) and non_depres-sion group (n=97).Both groups were given cardiopulmonary exercise testing (CPET).Results (1) Compared with Chinese norms , the scores on all subscales of SF_36 in 131 patients with CHD were lower ,and there were significant differences on all subscales of SF_36 except that related to social function ( P<0.01).Furthermore ,the scores on all subscales of SF_36 in depression group were lower than non_depression group ,there were significant differences on all subscales of SF_36 except those related to physical function and physical role (P<0.05 ,or P<0.01). (2) The peak oxygen consumption (VO2peak:) ,threshold of oxygen consumption of anaerobic metabolism (VO2 AT ) ,threshold anaerobic metabolism load (LoadAT ) in depression group were lower than those in non_de-pression.VO2peak:(17.3 ± 1.7)ml·kg-1·min-1 vs. (18.6 ± 2.9)ml·kg-1·min-1 , P<0.05;VO2AT:(12.0 ± 1.7)ml·kg-1· min-1 vs.(13.2 ± 2.2)ml·kg-1·min-1 ,P<0.01;LoadAT :(30.7 ± 11.4)J·s-1 vs.(36.0 ± 13.9)J·s-1 ,P<0.05.(3) In patients with CHD ,the scores of SF_36 and exercise tolerance were significantly correlated ( P<0.05);the scores on all subscales of SF_36 measured by BDI were significantly negatively correlated (P<0.05);the scores measured by BDI and VO2peak ,VO2AT ,LoadAT during CPET were significantly negatively correlated ( P<0.05 ). Conclusions Quality of life and exercise tolerance of patients with CHD complicating depression decreased severely ,and quality of life and exercise tolerance closely related to depression.