CAJ | 학술논문

目的：探讨在常规治疗基础上行早期连续性血液净化（CBP）治疗重症急性胰腺炎（SAP）的临床疗效。方法：将我科2011年5月至2013年4月收治的 SAP 患者36例随机分为对照组和治疗组各18例，对照组予常规治疗，治疗组在常规治疗基础上行早期 CBP 治疗，比较两组患者病死率及治疗前后1 d、3 d、5 d APACHEⅡ评分、血浆TNF-α和IL-8水平的变化。结果：治疗组的病死率5．6％小于对照组的22．2％，但差异无统计学意义（P＞0．05）；治疗组治疗后1 d、3 d、5 d APACHEⅡ评分、血浆 TNF-α和 IL-8水平较对照组均明显下降（P＜0．05）。结论：在常规治疗基础上实施早期 CBP治疗可改善SAP的临床症状，保护器官功能，改善预后。
목적：탐토재상규치료기출상행조기련속성혈액정화（CBP）치료중증급성이선염（SAP）적림상료효。방법：장아과2011년5월지2013년4월수치적 SAP 환자36례수궤분위대조조화치료조각18례，대조조여상규치료，치료조재상규치료기출상행조기 CBP 치료，비교량조환자병사솔급치료전후1 d、3 d、5 d APACHEⅡ평분、혈장TNF-α화IL-8수평적변화。결과：치료조적병사솔5．6％소우대조조적22．2％，단차이무통계학의의（P＞0．05）；치료조치료후1 d、3 d、5 d APACHEⅡ평분、혈장 TNF-α화 IL-8수평교대조조균명현하강（P＜0．05）。결론：재상규치료기출상실시조기 CBP치료가개선SAP적림상증상，보호기관공능，개선예후。
Objective: To explore the clinical efficacy of patients with severe acute pancreatitis (SAP) therapied by early continuous blood purification (CBP) based on the conventional treatment. Methods: 36 cases of SAP were randomly divided into control group accepted conventional treatment and treatment group accepted early CBP based on the conventional treatment,each group was 18 cases from May 2011 to Apr 2013. The mortality rate,APACHE II score and plasma levels of TNF-α and IL-8 were compared before treatment and 1 , 3 , 5 days after treatment between the two groups. Results: After early CBP treatment, the mortality rate was 5.56%, but there was 22.22% in control group, the difference was not statistically significant (P>0.05); On days 1, 3 and5, APACHE II score and plasma levels of TNF- α and IL-8 detection differed significantly between the control group and the test group (P<0.05). Conclusion: Early CBP can significantly improve clinical symptoms,protect organ function and improve the prognosis.