CAJ | 학술논문

目的：研究308 nm准分子激光对白癜风患者外周血Th1型细胞因子干扰素γ（ IFN-γ）和Th2型细胞因子白细胞介素-4（ IL-4）水平的影响，探讨其可能的作用机制。方法50例白癜风患者均采用308 nm准分子激光治疗，每周2次共治疗24次。采用酶联免疫吸附法（ ELISA法）检测50例白癜风患者治疗前、后及20例正常健康者外周血IFN-γ及IL-4的水平，并统计临床疗效。结果治疗组治疗前IFN-γ水平较正常对照组升高，比较差异有统计学意义（P＜0．05）；治疗后较治疗前明显降低（P＜0．05），且与正常对照组比较差异无统计学意义（P＞0．05）。治疗组治疗前IL-4水平与正常对照组及本组治疗后比较差异均无统计学意义（ P＞0．05）。结论白癜风患者体内Th1型细胞因子占优势，308 nm准分子激光可恢复白癜风患者Th1及Th2的平衡状态。
목적：연구308 nm준분자격광대백전풍환자외주혈Th1형세포인자간우소γ（ IFN-γ）화Th2형세포인자백세포개소-4（ IL-4）수평적영향，탐토기가능적작용궤제。방법50례백전풍환자균채용308 nm준분자격광치료，매주2차공치료24차。채용매련면역흡부법（ ELISA법）검측50례백전풍환자치료전、후급20례정상건강자외주혈IFN-γ급IL-4적수평，병통계림상료효。결과치료조치료전IFN-γ수평교정상대조조승고，비교차이유통계학의의（P＜0．05）；치료후교치료전명현강저（P＜0．05），차여정상대조조비교차이무통계학의의（P＞0．05）。치료조치료전IL-4수평여정상대조조급본조치료후비교차이균무통계학의의（ P＞0．05）。결론백전풍환자체내Th1형세포인자점우세，308 nm준분자격광가회복백전풍환자Th1급Th2적평형상태。
Objective To study the level of Th1 cytokine(IFN-γ) and Th2 cytokine (IL-4) in peripher-al blood of patients with vitiligo , and to explore the possible immune mechanism of 308 nm excimer laser for vitiligo therapy.Methods 50 cases of vitiligo were treated by 308nm excimer laser therapy , twice a week for 24 times.The level of IFN-γand IL-4 in peripheral blood from 50 vitiligo patients before and after treatment and 20 healthy per-son in control group were measured by enzyme linked immunosorbent assay .Results There was no difference be-tween two groups on the level of IL -4 (P>0.05).The level of IFN-γin vitiligo patients was higher than that in the control group (P<0.05); After 308nm excimer laser therapy the level of IFN -γin vitiligo patients was dis-creased significanlty (P<0.05).There was no significant difference between two groups after treatment (P>0.05). Conclusion Th1 cytokine take advantage of vitiligo patients and involved in the pathogenesis of vitiligo .308nm ex-cimer laser therapy can restore the Th 1/Th2 balance .