河北中医
河北中醫
하북중의
HEBEI JORNAL OF TRADITIONAL CHINESE MEDICINE
2014年
3期
412-413,414
,共3页
刘素梅%靳文军%王献忠
劉素梅%靳文軍%王獻忠
류소매%근문군%왕헌충
肺心病%中药疗法%血液流变学%药物作用%注射剂%人参%附子
肺心病%中藥療法%血液流變學%藥物作用%註射劑%人參%附子
폐심병%중약요법%혈액류변학%약물작용%주사제%인삼%부자
Pulmonary heart disease%Traditional Chinese medicine therapy%Hemorheology%Pharmacological action%Injection%Ginseng%Monkshood
目的：观察参附注射液对肺源性心脏病（以简称肺心病）急性期血液流变学的影响。方法将142例肺心病急性期患者随机分为2组。对照组64例采用西医常规治疗，治疗组78例在对照组治疗基础上加用参附注射液。2组疗程均为14 d。观察2组治疗前后心功能及血液流变学指标的变化，并判断临床疗效。结果2组治疗后全血黏度（低切、高切）、血浆黏度、血浆纤维蛋白原含量与本组治疗前比较均降低（P＜0．01，P＜0．05），左室射血分数和每搏输出量均增加（P＜0．05）；治疗组治疗后左室射血分数、每搏输出量均高于对照组治疗后（P＜0．05），全血黏度（低切、高切）、血浆黏度均低于对照组治疗后（P＜0．05）。治疗组总有效率88．5％，对照组总有效率71．8％，2组比较差异有统计学意义（ P＜0．05），治疗组疗效优于对照组。结论参附注射液联合常规西药疗法可明显改善心功能各项指标，其作用机制可能与其改善患者血液黏度有关。
目的：觀察參附註射液對肺源性心髒病（以簡稱肺心病）急性期血液流變學的影響。方法將142例肺心病急性期患者隨機分為2組。對照組64例採用西醫常規治療，治療組78例在對照組治療基礎上加用參附註射液。2組療程均為14 d。觀察2組治療前後心功能及血液流變學指標的變化，併判斷臨床療效。結果2組治療後全血黏度（低切、高切）、血漿黏度、血漿纖維蛋白原含量與本組治療前比較均降低（P＜0．01，P＜0．05），左室射血分數和每搏輸齣量均增加（P＜0．05）；治療組治療後左室射血分數、每搏輸齣量均高于對照組治療後（P＜0．05），全血黏度（低切、高切）、血漿黏度均低于對照組治療後（P＜0．05）。治療組總有效率88．5％，對照組總有效率71．8％，2組比較差異有統計學意義（ P＜0．05），治療組療效優于對照組。結論參附註射液聯閤常規西藥療法可明顯改善心功能各項指標，其作用機製可能與其改善患者血液黏度有關。
목적：관찰삼부주사액대폐원성심장병（이간칭폐심병）급성기혈액류변학적영향。방법장142례폐심병급성기환자수궤분위2조。대조조64례채용서의상규치료，치료조78례재대조조치료기출상가용삼부주사액。2조료정균위14 d。관찰2조치료전후심공능급혈액류변학지표적변화，병판단림상료효。결과2조치료후전혈점도（저절、고절）、혈장점도、혈장섬유단백원함량여본조치료전비교균강저（P＜0．01，P＜0．05），좌실사혈분수화매박수출량균증가（P＜0．05）；치료조치료후좌실사혈분수、매박수출량균고우대조조치료후（P＜0．05），전혈점도（저절、고절）、혈장점도균저우대조조치료후（P＜0．05）。치료조총유효솔88．5％，대조조총유효솔71．8％，2조비교차이유통계학의의（ P＜0．05），치료조료효우우대조조。결론삼부주사액연합상규서약요법가명현개선심공능각항지표，기작용궤제가능여기개선환자혈액점도유관。
Objective To investigate the effect of Shenfu injection on hemorheology of patient with pulmo -nary heart disease in acute phase .Methods 142 patients with pulmonary heart disease in acute phase were random-ly divided into two groups .64 cases in control group were treated by routine therapy .78 cases in treatment group were treated by Shenfu injection on the basis of control group treatment .The course was 14 days in two groups .The changes of cardiac function and hemorheology before and after treatment were observed and effect was evaluated in two groups . Results Whole blood viscosity ,plasma viscosity and fibrinogen content after treatment were reduced as compared with those before treatment in two groups (P<0.05).Left ventricular ejection fraction (LVEF) and stroke volume (SV) were increased (P<0.05).LVEF and SV in treatment group were higher than those in control group after treatment (P<0.05).Whole blood viscosity and plasma viscosity in treatment group were lower than those in control group after treatment (P<0.05).The total effective rate in treatment group (88.5%) was higher than that in control group (71.8%,P<0.05).Conclusion Shenfu injection combined with Conventional medicine therapy can obvi -ously improve indicators of cardiac function ,the mechanism maybe related to improving blood viscosity .
