中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2014年
4期
37-39
,共3页
下肢动脉硬化闭塞症%中西医结合%血液流变学%Hcy%ABI%PWV
下肢動脈硬化閉塞癥%中西醫結閤%血液流變學%Hcy%ABI%PWV
하지동맥경화폐새증%중서의결합%혈액류변학%Hcy%ABI%PWV
Lower extremity arteriosclerosis obliterans%Integrative medicine%Hemorheology%Hcy%ABI%PWV
目的：拟通过观察自拟中药汤剂联合凯时（前列腺素E1）治疗下肢动脉硬化闭塞症（ASO）的临床疗效，探讨其可能的作用机制。方法：将入选的30例ASO患者随机分成两组，治疗组予自拟中药汤剂水煎服，1剂/d，配合凯时10μg/d，静点；对照组仅予凯时静点治疗。10d为1个疗程，3个疗程后进行疗效评定，同时观察治疗前后患者血液流变学、同型半胱氨酸（Hcy）的改变，应用动脉硬化检测仪分别观察治疗前和治疗后踝肱指数（ABI）及颈动脉-股动脉脉搏传导速度（PWV）等指标的改善情况等。结果：治疗组总有效率86.67%；对照组总有效率73.33%，两组比较有统计学意义（P<0.05）。与治疗前比较，治疗后血液流变学、Hcy、ABI、PWV均有改善；与对照组比较有统计学意义（P<0.05）。结论：中药汤剂联合凯时通过降低血液黏度，缓解高凝状态和通过改善动脉僵硬度，使血管获益达到治疗ASO的目的。
目的：擬通過觀察自擬中藥湯劑聯閤凱時（前列腺素E1）治療下肢動脈硬化閉塞癥（ASO）的臨床療效，探討其可能的作用機製。方法：將入選的30例ASO患者隨機分成兩組，治療組予自擬中藥湯劑水煎服，1劑/d，配閤凱時10μg/d，靜點；對照組僅予凱時靜點治療。10d為1箇療程，3箇療程後進行療效評定，同時觀察治療前後患者血液流變學、同型半胱氨痠（Hcy）的改變，應用動脈硬化檢測儀分彆觀察治療前和治療後踝肱指數（ABI）及頸動脈-股動脈脈搏傳導速度（PWV）等指標的改善情況等。結果：治療組總有效率86.67%；對照組總有效率73.33%，兩組比較有統計學意義（P<0.05）。與治療前比較，治療後血液流變學、Hcy、ABI、PWV均有改善；與對照組比較有統計學意義（P<0.05）。結論：中藥湯劑聯閤凱時通過降低血液黏度，緩解高凝狀態和通過改善動脈僵硬度，使血管穫益達到治療ASO的目的。
목적：의통과관찰자의중약탕제연합개시（전렬선소E1）치료하지동맥경화폐새증（ASO）적림상료효，탐토기가능적작용궤제。방법：장입선적30례ASO환자수궤분성량조，치료조여자의중약탕제수전복，1제/d，배합개시10μg/d，정점；대조조부여개시정점치료。10d위1개료정，3개료정후진행료효평정，동시관찰치료전후환자혈액류변학、동형반광안산（Hcy）적개변，응용동맥경화검측의분별관찰치료전화치료후과굉지수（ABI）급경동맥-고동맥맥박전도속도（PWV）등지표적개선정황등。결과：치료조총유효솔86.67%；대조조총유효솔73.33%，량조비교유통계학의의（P<0.05）。여치료전비교，치료후혈액류변학、Hcy、ABI、PWV균유개선；여대조조비교유통계학의의（P<0.05）。결론：중약탕제연합개시통과강저혈액점도，완해고응상태화통과개선동맥강경도，사혈관획익체도치료ASO적목적。
Objective: To investigate the mechanism of action on treating lower extremity arteriosclerosis obliterans by TCM combined with Kaishi (prostaglandin E1). Methods:30 cases were randomly divided into two groups, in the treated group was treated by TCM, 1 agent/d, with Kay at 10μg/d, static point;the control group was treated by Kaishi. 10 days are 1 treatment course, after 3 courses of curative effect evaluation, to observe the changes of Blood rheology, homocysteine (Hcy) before and after treatment, and to observe the improve situation of the ankle brachial index (ABI) and carotid femoral pulse wave velocity (PWV) and other indicators by arteriosclerosis detector. Results:The treated group total efficiency 86.67%;control group total efficiency 73.33%, two groups was statistically significant (P<0.05). After treatment blood rheology, Hcy, ABI, PWV were improved; there was statistical significance compared with the control group (P<0.05). Conclusion: Treating lower extremity arteriosclerosis obliterans by TCM combined with Kaishi, by reducing the blood viscosity, relieve the hypercoagulability, through the improvement of arterial stiffness to the vascular benefits, achieve the purpose of treatment of ASO.
