CAJ | 학술논문

目的：探讨莪术油注射液配合常规化疗临床应用在卵巢癌治疗中的作用。方法：2009年9月～2011年12月收治经病理组织或细胞学诊断的卵巢癌患者62例，随机分为两组。两组患者均采用多烯紫杉醇联合顺铂治疗方案，即在化疗第1d、第8d和第15d静脉滴注多烯紫杉醇75mg/m2；第1～3d静脉滴注顺铂30mg/m2，每21d为1个周期；治疗组在上述治疗的基础上配合应用莪术油注射液400mg加入0.9%NS 500ml，静脉滴注，1次/d。结果：治疗组总有效率（CR＋PR）为74.19%；对照组总有效率（CR＋PR）为58.06%。两组比较，差异存在统计学意义（P<0.05），治疗组除过敏反应外，发生率与对照组持平，其他不良反应发生率均低于对照组（P<0.05，P<0.01）。结论：以多烯紫杉醇为核心的联合化疗对卵巢癌有较为肯定的近期疗效，而莪术油注射液有提高化疗疗效，减轻化疗不良反应的作用。
목적：탐토아술유주사액배합상규화료림상응용재란소암치료중적작용。방법：2009년9월～2011년12월수치경병리조직혹세포학진단적란소암환자62례，수궤분위량조。량조환자균채용다희자삼순연합순박치료방안，즉재화료제1d、제8d화제15d정맥적주다희자삼순75mg/m2；제1～3d정맥적주순박30mg/m2，매21d위1개주기；치료조재상술치료적기출상배합응용아술유주사액400mg가입0.9%NS 500ml，정맥적주，1차/d。결과：치료조총유효솔（CR＋PR）위74.19%；대조조총유효솔（CR＋PR）위58.06%。량조비교，차이존재통계학의의（P<0.05），치료조제과민반응외，발생솔여대조조지평，기타불량반응발생솔균저우대조조（P<0.05，P<0.01）。결론：이다희자삼순위핵심적연합화료대란소암유교위긍정적근기료효，이아술유주사액유제고화료료효，감경화료불량반응적작용。
Objective:To investigate the effect of curcuma oil injection plus conventional chemotherapy on treating ovarian cancer. Methods:From September 2009 to December 2011, 62 patients with ovarian cancer were randomly divided into two groups. Two groups of patients were treated with docetaxel plus cisplatin regimen, in the first day, eighth days and fifteenth days of chemotherapy intravenous infusion docetaxel 75mg/m2;from first to third days intravenous infusion cisplatin 30mg/m2, every 21 days for 1 cycle. The treated group based on that was given curcuma oil injection 400 mg adds 0.9%NS 500ml, intravenous infusion, once daily. Results:The total efficiency in treated group (CR+PR) was 74.19%; in the control group (CR+PR) was 58.06%. In two groups, there were statistically significant differences (P<0.05). In the treated group, in addition to allergic reactions, the incidence were flat with the control group, other adverse reaction rate were lower than the control group (P<0.05, P<0.01). Conclusion:Combination chemotherapy with docetaxel as the core of the short-term effect is sure to ovarian cancer, and curcuma oil injection improve chemotherapy efficacy, reduce the side effects of the chemotherapy.