岭南急诊医学杂志
嶺南急診醫學雜誌
령남급진의학잡지
LINGNAN JOURNAL OF EMERGENCY MEDICINE
2014年
2期
105-106,114
,共3页
糖尿病足%前列地尔%硫辛酸%临床疗效
糖尿病足%前列地爾%硫辛痠%臨床療效
당뇨병족%전렬지이%류신산%림상료효
diabetic foot%alprostadil%lipoic acid%clinical effect
目的：探讨前列地尔联合硫辛酸治疗糖尿病足的临床效果和安全性。方法：将2009年1月至2012年12月收治的糖尿病足患者101例随机分为对照组（n＝49）和治疗组（n＝52），对照组予以严格控制血糖、血压、清创、改善循环、抗感染等常规治疗，治疗组在对照组治疗的基础上加用前列地尔10 ug 加入生理盐水100 ml中静脉滴注，每日一次，硫辛酸300 mg 加入生理盐水250 ml 中静脉滴注，每日一次，2周为一疗程，比较2疗程后两组的临床疗效和不良反应。结果：治疗组总有效率92．3％（48/52）明显高于对照组的67．4％（33/49），P＜0．01；两组均未发现明显毒副作用。结论：在常规治疗的基础上，加用前列地尔和硫辛酸治疗糖尿病足能提高疗效，且无明显副作用。
目的：探討前列地爾聯閤硫辛痠治療糖尿病足的臨床效果和安全性。方法：將2009年1月至2012年12月收治的糖尿病足患者101例隨機分為對照組（n＝49）和治療組（n＝52），對照組予以嚴格控製血糖、血壓、清創、改善循環、抗感染等常規治療，治療組在對照組治療的基礎上加用前列地爾10 ug 加入生理鹽水100 ml中靜脈滴註，每日一次，硫辛痠300 mg 加入生理鹽水250 ml 中靜脈滴註，每日一次，2週為一療程，比較2療程後兩組的臨床療效和不良反應。結果：治療組總有效率92．3％（48/52）明顯高于對照組的67．4％（33/49），P＜0．01；兩組均未髮現明顯毒副作用。結論：在常規治療的基礎上，加用前列地爾和硫辛痠治療糖尿病足能提高療效，且無明顯副作用。
목적：탐토전렬지이연합류신산치료당뇨병족적림상효과화안전성。방법：장2009년1월지2012년12월수치적당뇨병족환자101례수궤분위대조조（n＝49）화치료조（n＝52），대조조여이엄격공제혈당、혈압、청창、개선순배、항감염등상규치료，치료조재대조조치료적기출상가용전렬지이10 ug 가입생리염수100 ml중정맥적주，매일일차，류신산300 mg 가입생리염수250 ml 중정맥적주，매일일차，2주위일료정，비교2료정후량조적림상료효화불량반응。결과：치료조총유효솔92．3％（48/52）명현고우대조조적67．4％（33/49），P＜0．01；량조균미발현명현독부작용。결론：재상규치료적기출상，가용전렬지이화류신산치료당뇨병족능제고료효，차무명현부작용。
Objective: To explore the clinical effect and safety patients with diabetic foot treated adjunctively by alprostadil combined with lipoic acid. Methods: 101 patients with diabetic foot were randomly divided into the control group(n=49) and the treatment group(n=52). The patients in the control group were treated by routine treatments, such as the strict control of blood glucose,blood pressure,debridement,improving circulation,anti-infection and so on. The patients in the treatment group was added with alprostadil (alprostadil 10 ug plus Normal saline 100ml intravenously,once a day)and lipoic acid (lipoic acid 300mg plus Normal saline 250 ml intravenously,once a day), one course of treatment including two weeks. The clinical effect and the side effect were compared between the two groups after thee two courses. Results: The total effective rate was significantly higher in the treatment group than that in the control group [92.3%(48/52) & 67.4%(33/49)],P<0.01. There was no obvious toxic and side effect between the two groups. Conclusion: Alprostadil combined with lipoic acid in the assistant-treatment of patients with diabetic foot can effectively improve the clinical effect and without obviousside effects.
