河北医学
河北醫學
하북의학
HEBEI MEDICINE
2014年
8期
1298-1300
,共3页
充血性心力衰竭%N端脑钠肽前体%心率变异性
充血性心力衰竭%N耑腦鈉肽前體%心率變異性
충혈성심력쇠갈%N단뇌납태전체%심솔변이성
CHF%NT-proBNP%HRV
目的：分析充血性心力衰竭（ CHF）患者N端脑钠肽前体（ NT-proBNP ）浓度变化水平和心率变异性（HRV）与心功能的相关性。方法：选择82例CHF患者（观察组，n＝82）和30例健康体检者（对照组，n＝30）作为研究对象，观察组患者依照HYHA标准分为Ⅰ组、Ⅱ组、Ⅲ组和Ⅳ组；比较观察组和对照组NT-proBNP 水平和HRV指标变化情况。结果：观察组中的Ⅱ组、Ⅲ组和Ⅳ组NT-proBNP浓度变化水平存在显著差异（P＜0．05），且均高于对照组（P＜0．01）；观察组患者HRV指标显著高于健康组（P＜0．01），且Ⅰ组、Ⅱ组HRV 指标显著高于Ⅲ组和Ⅳ组（P＜0．05）；经多元回归分析，各组NT-proBNP 浓度与LVEF、LVDED存在相关性，LVEF、LVDED与RMSSD和PNN50相关。结论：CHF患者clNT-proBNP 水平和心率变异性均与患者的心功能存在显著相关性；NT-proBNP 水平能够为CHF的临床诊断、治疗、预后判定提供准确与量化的依据；CHF患者的HRV指标减低则提示心功能较差，且减低幅度越大，则心功能越差。
目的：分析充血性心力衰竭（ CHF）患者N耑腦鈉肽前體（ NT-proBNP ）濃度變化水平和心率變異性（HRV）與心功能的相關性。方法：選擇82例CHF患者（觀察組，n＝82）和30例健康體檢者（對照組，n＝30）作為研究對象，觀察組患者依照HYHA標準分為Ⅰ組、Ⅱ組、Ⅲ組和Ⅳ組；比較觀察組和對照組NT-proBNP 水平和HRV指標變化情況。結果：觀察組中的Ⅱ組、Ⅲ組和Ⅳ組NT-proBNP濃度變化水平存在顯著差異（P＜0．05），且均高于對照組（P＜0．01）；觀察組患者HRV指標顯著高于健康組（P＜0．01），且Ⅰ組、Ⅱ組HRV 指標顯著高于Ⅲ組和Ⅳ組（P＜0．05）；經多元迴歸分析，各組NT-proBNP 濃度與LVEF、LVDED存在相關性，LVEF、LVDED與RMSSD和PNN50相關。結論：CHF患者clNT-proBNP 水平和心率變異性均與患者的心功能存在顯著相關性；NT-proBNP 水平能夠為CHF的臨床診斷、治療、預後判定提供準確與量化的依據；CHF患者的HRV指標減低則提示心功能較差，且減低幅度越大，則心功能越差。
목적：분석충혈성심력쇠갈（ CHF）환자N단뇌납태전체（ NT-proBNP ）농도변화수평화심솔변이성（HRV）여심공능적상관성。방법：선택82례CHF환자（관찰조，n＝82）화30례건강체검자（대조조，n＝30）작위연구대상，관찰조환자의조HYHA표준분위Ⅰ조、Ⅱ조、Ⅲ조화Ⅳ조；비교관찰조화대조조NT-proBNP 수평화HRV지표변화정황。결과：관찰조중적Ⅱ조、Ⅲ조화Ⅳ조NT-proBNP농도변화수평존재현저차이（P＜0．05），차균고우대조조（P＜0．01）；관찰조환자HRV지표현저고우건강조（P＜0．01），차Ⅰ조、Ⅱ조HRV 지표현저고우Ⅲ조화Ⅳ조（P＜0．05）；경다원회귀분석，각조NT-proBNP 농도여LVEF、LVDED존재상관성，LVEF、LVDED여RMSSD화PNN50상관。결론：CHF환자clNT-proBNP 수평화심솔변이성균여환자적심공능존재현저상관성；NT-proBNP 수평능구위CHF적림상진단、치료、예후판정제공준학여양화적의거；CHF환자적HRV지표감저칙제시심공능교차，차감저폭도월대，칙심공능월차。
Objective:To analyze the correlation between NT-proBNP level and heart rate variability and cardiac function of patients with CHF .Method:82 cases with CHF ( the observation group , n=82) and 30 healthy examiners ( the control group , n=30 ) were selected as research objects .According to HYHA standard , the observation group was divided into group Ⅰ, group Ⅱ, group Ⅲand group Ⅳ.NT-proBNP level and HRV index of the observation group and the control group were compared .Result:There was evi-dent difference for NT-proBNP level in group Ⅱ, group Ⅲ and group Ⅳ of the observation group ( P<0. 05), and were higher than that of the control group (P<0.01).HRV index of the observation group was evi-dently higher than that of control group ( P<0.01) , and that in groupⅠ, groupⅡwas evidently higher than that in group Ⅲand group Ⅳ(P<0.05).Through multivariate regression analysis , there was correlation be-tween NT-proBNP concentration and LVEF , LVDED.LVEF, LVDED and RMSSD correlate with NN 50. Conclusion:NT-proBNP level and heart rate variability of patients with CHF has evident correlation with cardiac function of patients .NT-proBNP level can provide accurate and quantitative basis for clinical diagno-sis, treatment and prognosis for CHF .The reduction of HRV indicator for patients with CHF indicates bad cardiac function .The greater the reduction amplitude is , the worse the cardiac function is .
