河北医学
河北醫學
하북의학
HEBEI MEDICINE
2014年
8期
1284-1287
,共4页
吕俊宏%彭盘俐%林少欢%蔡长青%李玉婵
呂俊宏%彭盤俐%林少歡%蔡長青%李玉嬋
려준굉%팽반리%림소환%채장청%리옥선
乳腺癌%Her2%TopoⅡ%新辅助化疗%疗效
乳腺癌%Her2%TopoⅡ%新輔助化療%療效
유선암%Her2%TopoⅡ%신보조화료%료효
Breast cancer%Her2%TopoII%Neoadjuvant chemotherapy%Curative effect
目的:探讨乳腺癌组织人类表皮生长因子受体2( Her2)、拓扑异构酶Ⅱ(Topo Ⅱ)表达水平与新辅助化疗近远期疗效的关系。方法:选取96例 TEC 方案新辅助化疗乳腺癌患者,化疗前穿刺活检术与化疗后手术采集病灶组织,采用免疫组化法检测组织Her2、TopoⅡ表达水平。结果:新辅助化疗后,Her2、TopoⅡ阳性表达率(60.42%、80.21%)较化疗前(88.54%、92.71%)显著降低(P<0.05);且有效组的Her 2、TopoⅡ阳性表达率显著低于无效组,阴性表达率显著高于无效组,两组比较差异具有统计学意义(P<0.05),Her2、TopoⅡ阴性组的化疗有效率与1、3、5年生存率均显著高于阳性组,两组比较差异性显著( P<0.05)。结论:新辅助化疗通过降低乳腺癌组织Her2、TopoⅡ阳性表达以增强患者的化疗效果,且Her2、TopoⅡ表达水平在近远期疗效的预测中具有重要的临床价值。
目的:探討乳腺癌組織人類錶皮生長因子受體2( Her2)、拓撲異構酶Ⅱ(Topo Ⅱ)錶達水平與新輔助化療近遠期療效的關繫。方法:選取96例 TEC 方案新輔助化療乳腺癌患者,化療前穿刺活檢術與化療後手術採集病竈組織,採用免疫組化法檢測組織Her2、TopoⅡ錶達水平。結果:新輔助化療後,Her2、TopoⅡ暘性錶達率(60.42%、80.21%)較化療前(88.54%、92.71%)顯著降低(P<0.05);且有效組的Her 2、TopoⅡ暘性錶達率顯著低于無效組,陰性錶達率顯著高于無效組,兩組比較差異具有統計學意義(P<0.05),Her2、TopoⅡ陰性組的化療有效率與1、3、5年生存率均顯著高于暘性組,兩組比較差異性顯著( P<0.05)。結論:新輔助化療通過降低乳腺癌組織Her2、TopoⅡ暘性錶達以增彊患者的化療效果,且Her2、TopoⅡ錶達水平在近遠期療效的預測中具有重要的臨床價值。
목적:탐토유선암조직인류표피생장인자수체2( Her2)、탁복이구매Ⅱ(Topo Ⅱ)표체수평여신보조화료근원기료효적관계。방법:선취96례 TEC 방안신보조화료유선암환자,화료전천자활검술여화료후수술채집병조조직,채용면역조화법검측조직Her2、TopoⅡ표체수평。결과:신보조화료후,Her2、TopoⅡ양성표체솔(60.42%、80.21%)교화료전(88.54%、92.71%)현저강저(P<0.05);차유효조적Her 2、TopoⅡ양성표체솔현저저우무효조,음성표체솔현저고우무효조,량조비교차이구유통계학의의(P<0.05),Her2、TopoⅡ음성조적화료유효솔여1、3、5년생존솔균현저고우양성조,량조비교차이성현저( P<0.05)。결론:신보조화료통과강저유선암조직Her2、TopoⅡ양성표체이증강환자적화료효과,차Her2、TopoⅡ표체수평재근원기료효적예측중구유중요적림상개치。
Objective:To study relativity between human epidermal growth factor receptor 2 ( Her2 ) , topoisomerase II(Topo II)expression level in breast cancer tissue and short /long-term effect of neoadjuvant chemotherapy .Method:96 cases TEC neoadjuvant chemotherapy breast cancer patients were selected , using biopsy before chemotherapy and surgery after chemotherapy to collect lesions and immunohistochemical meth -od to detect level of tissue Her 2, Topo II expression .Result:After neoadjuvant chemotherapy , Her2, Topo II positive expression rate (60.42%, 80.21%) significantly decreased than before (88.54%, 88.54%) (P <0.05); And Her2, Topo II positive expression rate of effective group were significantly lower than ineffective group, Her2, Topo II negative expression rate were also significantly higher than ineffective group ( P <0. 05), and effective rate and 1, 3, 5 year survival rates in Her2, Topo II negative groups were significantly higher than those in positive group (P <0.05).Conclusion:Neoadjuvant chemotherapy can reduce breast tissue Her2, Topo II positive expression to enhance chemotherapy effect , and Her2, Topo II expression level has important clinical value in predicting of short/long-term effect.