河北医药
河北醫藥
하북의약
HEBEI MEDICAL JOURNAL
2014年
5期
648-651
,共4页
方浩%何杰%左盼莉%李晓娜%崔建岭
方浩%何傑%左盼莉%李曉娜%崔建嶺
방호%하걸%좌반리%리효나%최건령
骨密度%骨质疏松%磁共振弥散成像%计算机体层摄影术
骨密度%骨質疏鬆%磁共振瀰散成像%計算機體層攝影術
골밀도%골질소송%자공진미산성상%계산궤체층섭영술
bone density%osteoporosis%magnetic resonance diffusion weighted imaging%computed tomography
目的：探讨腰椎椎体表观弥散系数（ apparent diffusion coefficient ，ADC）值与定量CT（ quantitative compu-ted tomography，QCT）所测骨密度（bone mineral density，BMD）的相关性。方法对121例腰腿痛患者进行腰2～4椎体QCT检查，并根据骨密度分为骨密度正常组、骨密度减少组及骨质疏松组。再对患者进行腰椎MR检查，先行常规矢状面T2WI、T1 WI和横轴面T2WI扫描；弥散加权成像（diffusion weighted imaging，DWI）采用自旋回波单次激发回波平面成像序列（ b值为0和600 s/mm2），行椎体矢状位DWI扫描，在ADC图上测量腰2～4椎体ADC值。最后分析ADC值与骨密度的相关性。结果男性各组间ADC值差异无统计学意义（ P ＞0)．05）；女性骨密度正常组ADC（0．45±0．13）×10-3 mm2/s，与骨量减少组（0．302±0．0677）×10-3 mm2s/及骨质疏松组（0．2869±0．0475）×10-3 mm2/s比较，差异有统计学意义（ P ＜0．05）。 Spearman相关分析发现，男性BMD与ADC值无相关性，女性BMD与ADC值呈正相关（ r ＝0．545， P ＜0．01）。结论 DWI可从骨髓分子运动水平研究骨质疏松的病理生理变化，对骨质疏松进行无创性定量评估。
目的：探討腰椎椎體錶觀瀰散繫數（ apparent diffusion coefficient ，ADC）值與定量CT（ quantitative compu-ted tomography，QCT）所測骨密度（bone mineral density，BMD）的相關性。方法對121例腰腿痛患者進行腰2～4椎體QCT檢查，併根據骨密度分為骨密度正常組、骨密度減少組及骨質疏鬆組。再對患者進行腰椎MR檢查，先行常規矢狀麵T2WI、T1 WI和橫軸麵T2WI掃描；瀰散加權成像（diffusion weighted imaging，DWI）採用自鏇迴波單次激髮迴波平麵成像序列（ b值為0和600 s/mm2），行椎體矢狀位DWI掃描，在ADC圖上測量腰2～4椎體ADC值。最後分析ADC值與骨密度的相關性。結果男性各組間ADC值差異無統計學意義（ P ＞0)．05）；女性骨密度正常組ADC（0．45±0．13）×10-3 mm2/s，與骨量減少組（0．302±0．0677）×10-3 mm2s/及骨質疏鬆組（0．2869±0．0475）×10-3 mm2/s比較，差異有統計學意義（ P ＜0．05）。 Spearman相關分析髮現，男性BMD與ADC值無相關性，女性BMD與ADC值呈正相關（ r ＝0．545， P ＜0．01）。結論 DWI可從骨髓分子運動水平研究骨質疏鬆的病理生理變化，對骨質疏鬆進行無創性定量評估。
목적：탐토요추추체표관미산계수（ apparent diffusion coefficient ，ADC）치여정량CT（ quantitative compu-ted tomography，QCT）소측골밀도（bone mineral density，BMD）적상관성。방법대121례요퇴통환자진행요2～4추체QCT검사，병근거골밀도분위골밀도정상조、골밀도감소조급골질소송조。재대환자진행요추MR검사，선행상규시상면T2WI、T1 WI화횡축면T2WI소묘；미산가권성상（diffusion weighted imaging，DWI）채용자선회파단차격발회파평면성상서렬（ b치위0화600 s/mm2），행추체시상위DWI소묘，재ADC도상측량요2～4추체ADC치。최후분석ADC치여골밀도적상관성。결과남성각조간ADC치차이무통계학의의（ P ＞0)．05）；녀성골밀도정상조ADC（0．45±0．13）×10-3 mm2/s，여골량감소조（0．302±0．0677）×10-3 mm2s/급골질소송조（0．2869±0．0475）×10-3 mm2/s비교，차이유통계학의의（ P ＜0．05）。 Spearman상관분석발현，남성BMD여ADC치무상관성，녀성BMD여ADC치정정상관（ r ＝0．545， P ＜0．01）。결론 DWI가종골수분자운동수평연구골질소송적병리생리변화，대골질소송진행무창성정량평고。
Objective To investigate the correlation between apparent diffusion coefficient ( ADC ) detected by magnetic resonance ( MR) diffusion weighted imaging ( DWI ) and bone mineral density ( BMD ) measured by quantitative computed tomography ( QCT) in human lumbar spine .Methods 121 patients with lumbocrural pain underwent volumetric bone mineral density measured by QCT at the site of lumbar spine ( L2~4 ) .According to the bone mineral density , all the subjects were divided into three groups:normal bone density group , osteoporosis group , osteopenia group .After routine MRI examination (Sagittal T2WI,T1WI and Axial T2WI),DWI was performed with single shot spin -echo planar imaging sequence ( b =0,600 s/mm2 ) and ADC values were measured .Finally the correlation between ADC and BMD was analyzed . Results There were no significant differences in ADC values among different male groups .As compared with those in normal bone density group,ADC values were significantly decreased in osteoporosis group [(0.2869 ±0.0475) ×10 -3 mm2/s vs (0.45 ±0.13) ×10 -3 mm2/s, P <0.01)] and in osteopenic group [(0.302 ±0.0677) ×10 -3 mm2/s vs (0.45 ±0.13) × 10 -3 mm2/s, P <0.01)] in females.ADC values were positively correlated with BMD values ( r =0.545, P <0.01) in females,but ADC values were not related to BMD values in males .Conclusion DWI can quantitatively evaluate osteoporosis noninvasively by observing the pathological changes of vertebral bone marrow at molecular movement level .
