CAJ | 학술논문

目的：探讨抗精神病药物齐拉西酮对精神分裂症患者心肌酶表达水平的影响。方法对63例精神分裂症患者进行齐拉西酮治疗，检测并比较治疗前后进行血清肌酸激酶（CK）、肌酸激酶同工酶MB（CK-MB）、乳酸脱氢酶（LD H ）水平。结果精神分裂症患者齐拉西酮治疗后1周末、4周末、24周末上述血清心肌酶水平与治疗前比较差异有统计学意义（P＜0．05）。结论长时间服用抗精神病药齐拉西酮可导致精神分裂症患者血清心肌酶代谢的异常。
목적：탐토항정신병약물제랍서동대정신분렬증환자심기매표체수평적영향。방법대63례정신분렬증환자진행제랍서동치료，검측병비교치료전후진행혈청기산격매（CK）、기산격매동공매MB（CK-MB）、유산탈경매（LD H ）수평。결과정신분렬증환자제랍서동치료후1주말、4주말、24주말상술혈청심기매수평여치료전비교차이유통계학의의（P＜0．05）。결론장시간복용항정신병약제랍서동가도치정신분렬증환자혈청심기매대사적이상。
Objective To investigate the effect of ziprasidone on myocardial enzymes in patients with schizo-phrenia .Methods Serum levels of myocardial enzymes ,including creatine kinase (CK ) ,creatine kinase isozyme MB (CK-MB) and lactate dehydrogenase (LDH) ,were detected and compared in 63 cases of patients with schizophrenia before and after the therapy of ziprasidone .Results Serum levels of CK ,CK-MB and LDH in patient with schizo-phrenia detected at 1 ,4 and 24 weeks after the therapy of ziprasidone were statistically different with that detected before therapy (P<0 .05) .Conclusion Long-term therapy of ziprasidone could induce the abnormality of the metab-olism of serum myocardial enzymes .