CAJ | 학술논문

目的：测定卵巢癌患者血清附睾蛋白4（HE4）和糖类抗原（CA）125水平，探讨血清HE4和CA125联合测定对卵巢癌的诊断价值。方法选择佛山市第一人民医院、佛山市第二人民医院、佛山中医院、佛山禅城区中心医院2012年1月至2013年5月收治的160例住院或门诊患者，将其分为卵巢癌组91例和卵巢良性肿瘤组69例。同时选择同期健康体检女性60例健康对照组。采用电化学发光免疫分析测定血清 HE4和CA125水平。并检测卵巢癌病理分期与 HE4、CA125水平的关系。结果卵巢癌患者血清 HE4、CA125水平均明显高于卵巢良性肿瘤组和健康对照组（P＜0．01）；指标单独检测，HE4敏感性、特异性和诊断效率均高于CA125；并联试验时，敏感性明显提高，串联试验时，特异性明显提高。单独和联合检测中，并联试验对卵巢癌阳性检出率最高。卵巢癌患者随着病理分期升高血清 HE4和CA125水平依次升高，但卵巢癌患者Ⅰ期血清CA125水平与卵巢良性肿瘤组比较，差异无统计学意义（P＞0．05）。结论与CA125相比，HE4为最佳单项卵巢癌肿瘤标志物，联合检测并联试验可提高诊断敏感性，串联试验可提高诊断特异性。
목적：측정란소암환자혈청부고단백4（HE4）화당류항원（CA）125수평，탐토혈청HE4화CA125연합측정대란소암적진단개치。방법선택불산시제일인민의원、불산시제이인민의원、불산중의원、불산선성구중심의원2012년1월지2013년5월수치적160례주원혹문진환자，장기분위란소암조91례화란소량성종류조69례。동시선택동기건강체검녀성60례건강대조조。채용전화학발광면역분석측정혈청 HE4화CA125수평。병검측란소암병리분기여 HE4、CA125수평적관계。결과란소암환자혈청 HE4、CA125수평균명현고우란소량성종류조화건강대조조（P＜0．01）；지표단독검측，HE4민감성、특이성화진단효솔균고우CA125；병련시험시，민감성명현제고，천련시험시，특이성명현제고。단독화연합검측중，병련시험대란소암양성검출솔최고。란소암환자수착병리분기승고혈청 HE4화CA125수평의차승고，단란소암환자Ⅰ기혈청CA125수평여란소량성종류조비교，차이무통계학의의（P＞0．05）。결론여CA125상비，HE4위최가단항란소암종류표지물，연합검측병련시험가제고진단민감성，천련시험가제고진단특이성。
Objective To explore the values of serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) in the diagnosis of ovarian cancer .Methods Serum levels of HE4 and CA125 were detected in 91 patients with ovarian cancer ,69 patients with benign ovarian diseases and 60 healthy females by using chemilumi-nescence immune assay .Results Serum levels of HE4 and CA125 in patients with ovarian cancer were significantly higher than patients with benign ovarian diseases and healthy subjects (P<0 .01) .The sensitivity ,specificity and di-agnostic performance of HE4 were higher than CA125 ,when being detected alone .Combined assay of parallel test of HE4 and CA125 could improve sensitivity and Combined assay of series test could improve specificity .Compared with individual and combined assay ,the positive detection rate of parallel test was higher .With the elevating of staging of ovarian cancer ,serum levels of HE4 and CA125 were also elevated .But there was no significant difference of serum CA125 level between patients with ovarian cancer at stage Ⅰand patients with benign ovarian tumors (P>0 .05) . Conclusion Compared with CA125 ,HE4 could be the best single tumor marker for diagnosis of ovarian cancer . Combined assay of parallel test could improve the diagnostic sensitivity and combined assay of series test could im-prove the diagnostic specificity .