检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
6期
747-748,751
,共3页
王志学%冀向宁%王文英%梁勇
王誌學%冀嚮寧%王文英%樑勇
왕지학%기향저%왕문영%량용
Eales病%一氧化氮%一氧化氮合酶%发病机制%激光光凝
Eales病%一氧化氮%一氧化氮閤酶%髮病機製%激光光凝
Eales병%일양화담%일양화담합매%발병궤제%격광광응
Eales disease%nitrogen monoxidum%nitrogen monoxidum synthase%pathogenesis%laser photocoagulation
目的:观察Eales病患者视网膜光凝治疗前后血浆一氧化氮(NO )水平及一氧化氮合酶(NOS )的活性。方法选择沧州市中心医院眼科2006年5月至2013年7月经临床确诊的Eales病患者104例(170眼)为观察组,按照眼底荧光血管造影结果,将观察组分为激光治疗患者60例(78眼),非激光治疗患者44例(92眼)。选择同期健康人群66例为健康对照组。对所有研究对象术前术后分别检测NO、NOS。结果观察组NO、总NOS及结构型NOS(cNOS)活性平均值低于健康对照组(P<0.05)。激光治疗和非激光治疗患者各指标比较,差异均无统计学意义(P>0.05)。激光治疗患者术前及术后NO、NOS比较,差异无统计学意义(P>0.05)。激光治疗患者中视力保持稳定或提高者共70眼(89.74%)。结论 NO与NOS可能参与 Eales病的发生发展,视网膜光凝治疗能有效控制Eales病的发展,但视网膜光凝治疗未能从根本上治疗Eales病。
目的:觀察Eales病患者視網膜光凝治療前後血漿一氧化氮(NO )水平及一氧化氮閤酶(NOS )的活性。方法選擇滄州市中心醫院眼科2006年5月至2013年7月經臨床確診的Eales病患者104例(170眼)為觀察組,按照眼底熒光血管造影結果,將觀察組分為激光治療患者60例(78眼),非激光治療患者44例(92眼)。選擇同期健康人群66例為健康對照組。對所有研究對象術前術後分彆檢測NO、NOS。結果觀察組NO、總NOS及結構型NOS(cNOS)活性平均值低于健康對照組(P<0.05)。激光治療和非激光治療患者各指標比較,差異均無統計學意義(P>0.05)。激光治療患者術前及術後NO、NOS比較,差異無統計學意義(P>0.05)。激光治療患者中視力保持穩定或提高者共70眼(89.74%)。結論 NO與NOS可能參與 Eales病的髮生髮展,視網膜光凝治療能有效控製Eales病的髮展,但視網膜光凝治療未能從根本上治療Eales病。
목적:관찰Eales병환자시망막광응치료전후혈장일양화담(NO )수평급일양화담합매(NOS )적활성。방법선택창주시중심의원안과2006년5월지2013년7월경림상학진적Eales병환자104례(170안)위관찰조,안조안저형광혈관조영결과,장관찰조분위격광치료환자60례(78안),비격광치료환자44례(92안)。선택동기건강인군66례위건강대조조。대소유연구대상술전술후분별검측NO、NOS。결과관찰조NO、총NOS급결구형NOS(cNOS)활성평균치저우건강대조조(P<0.05)。격광치료화비격광치료환자각지표비교,차이균무통계학의의(P>0.05)。격광치료환자술전급술후NO、NOS비교,차이무통계학의의(P>0.05)。격광치료환자중시력보지은정혹제고자공70안(89.74%)。결론 NO여NOS가능삼여 Eales병적발생발전,시망막광응치료능유효공제Eales병적발전,단시망막광응치료미능종근본상치료Eales병。
Objective To observe plasma level of nitrogen monoxidum (NO) and activity of nitrogen monoxi-dum synthase (NOS) in patients with Eales disease before and after laser photocoagulation .Methods A total of 104 patients (170 eyes) with Eales disease were enrolled as observation group ,and divided into laser therapy group (60 cases ,78 eyes) and non-laser therapy group (44 cases ,92 eyes) .And 66 healthy subjects were enrolled as control group .NO and NOS were detected in healthy subjects and patients before and after therapy .Results Plasma levels of NO and activity of total NOS and constitutive NOS (cNOS ) in observation group were lower than control group (P<0 .05) ,but there was no statistical difference between laser therapy group and non -laser therapy group (P<0 .05) .There was also no statistical difference of NO and NOS levels before and after laser therapy (P<0 .05) .In la-ser therapy group ,visual acuity of 70 eyes remained stable or improved after laser therapy ,accounting for 89 .74% . Conclusion NO and NOS might be associated with the occurrence and development of Eales disease .Laser treatment could effectively control the development of Eales disease ,but could not achieve complete cure .