CAJ | 학술논문

目的：探讨血清胱抑素C（Cys C）与β2微球蛋白（β2-MG）在慢性肾脏疾病（CKD）患者新分期中的临床诊断意义。方法选择解放军总医院2011年12月至2013年1月肾内科219例住院患者为研究对象，检测患者Cys C、β2-MG和其他肾功能指标，采用MDRD公式计算肾小球滤过率（eGFR）。分析Cys C、β2-MG与其他检测项目的相关性。结果 CKD不同分期患者Cys C和β2-MG指标差异有统计学意义（P＜0．05）。随着eGFR下降， Cys C和β2-MG在CKD新分期中呈明显升高趋势，差异有统计学意义（P＜0．05）。Cys C和β2-MG与肌酐、尿素氮有较好的相关性。结论 Cys C、β2-M G是用于评价CKD患者肾功能较好的实验室指标。
목적：탐토혈청광억소C（Cys C）여β2미구단백（β2-MG）재만성신장질병（CKD）환자신분기중적림상진단의의。방법선택해방군총의원2011년12월지2013년1월신내과219례주원환자위연구대상，검측환자Cys C、β2-MG화기타신공능지표，채용MDRD공식계산신소구려과솔（eGFR）。분석Cys C、β2-MG여기타검측항목적상관성。결과 CKD불동분기환자Cys C화β2-MG지표차이유통계학의의（P＜0．05）。수착eGFR하강， Cys C화β2-MG재CKD신분기중정명현승고추세，차이유통계학의의（P＜0．05）。Cys C화β2-MG여기항、뇨소담유교호적상관성。결론 Cys C、β2-M G시용우평개CKD환자신공능교호적실험실지표。
Objective To explore the clinical role of serum cystatin C andβ2-microglobumin in the new staging of patients with chronicle kidney disease .Methods Serum systatin C andβ2-microglobumin were analyzed in 219 pa-tients with chronic kidney disease and 35 healthy controls from December 2011 to January 2013 .The estimated glo-merular filtration rate (eGFR) was calculated using the modified Modification of Diet in Renal Disease (MDRD) e-quation .Results There were statistical significance between the patients with chronic kidney disease and healthy controls of the serum concentration of cystatin C and β2-microglobumin (P<0 .05) .The levels of serum cystatin C andβ2-microglobumin were increased with the decrease of the eGFR .It was statistical significant difference between the new stage of patients with chronic kidney disease for the serum cystatin C and β2-microglobumin (P<0 .05) .On linear regression ,the cystatin C andβ2-microglobumin were closely correlated to creatinine and urea .Conclusion Ser-um cystatin C andβ2-microglobumin might be sensitive indicators in judgment of renal damage of chronic kidney dis-ease and assessment of glomerular filtration rate .