CAJ | 학술논문

发展了一种制备含聚硅氧烷惰性长链的手性伯胺的方法，合成了一系列聚硅氧烷衍生的手性伯胺催化剂，并成功地应用于催化α，α，α-三氟苯乙酮和丙酮的不对称aldol反应，考察了酸、催化剂结构和溶剂对反应的影响。当采用催化剂A与Boc-L-苯丙氨酸所组成的催化体系在水相中催化α，α，α-三氟苯乙酮和丙酮的不对称aldol反应时，反应具有高产率（94％）和中等的对映选择性（54％ ee）。
발전료일충제비함취규양완타성장련적수성백알적방법，합성료일계렬취규양완연생적수성백알최화제，병성공지응용우최화α，α，α-삼불분을동화병동적불대칭aldol반응，고찰료산、최화제결구화용제대반응적영향。당채용최화제A여Boc-L-분병안산소조성적최화체계재수상중최화α，α，α-삼불분을동화병동적불대칭aldol반응시，반응구유고산솔（94％）화중등적대영선택성（54％ ee）。
A novel method to prepare chiral primary amines with polysiloxane inert long chain is successfully developed , a series of chiral primary amine catalysts derived from polysiloxane are synthesized ,and the asymmetric aldol reaction which is used to catalyze α,α,α-trifluoroacetophenone and acetone is carried out smoothly with these catalysts .The effects of acids ,the structure of the catalysts and solvents on the reaction are investigated .The asymmetric aldol reaction of α,α,α-trifluoroacetophenone and acetone catalyzed by catalyst A and Boc-L-phenylalanine in water phase exhibits excellent yield (94% ) and moderate enantioselectivity (54% ee) .