CAJ | 학술논문

Klotho基因是与衰老有关的基因，编码分泌型和膜型两种蛋白质，在全身多系统表达。其表达产物可以作为糖苷酶水解TRPC-6发挥心肌保护作用，抑制心肌肥大并减少冠心病的发生；并可以作为循环因子抑制胰岛素样生长因子（IGF）发挥抗衰老作用，抑制转化生长因子（TGF）-β1发挥肾脏保护及抗肿瘤作用；作为FGF-23的共受体而对钙磷代谢产生影响。Klotho基因表达的调节也非常复杂，但因其各个系统的抗衰老作用，越来越受到人们的关注。
Klotho기인시여쇠로유관적기인，편마분비형화막형량충단백질，재전신다계통표체。기표체산물가이작위당감매수해TRPC-6발휘심기보호작용，억제심기비대병감소관심병적발생；병가이작위순배인자억제이도소양생장인자（IGF）발휘항쇠로작용，억제전화생장인자（TGF）-β1발휘신장보호급항종류작용；작위FGF-23적공수체이대개린대사산생영향。Klotho기인표체적조절야비상복잡，단인기각개계통적항쇠로작용，월래월수도인문적관주。
Klotho gene is associated with aging, encoding two kind of protein: membrane protein and secreted protein. It is expressed in multiple systems. The protein can act as aglycosidase and hydrolyze TRPV-6, in turn to inhibit myocardial hypertrophy and reduce the occurrence of coronary heart disease, it also act as circulating factor, inhibit insulin-like growth factor (IGF) and plays a role of anti-aging protein, inhibit transforming growth factor (TGF)-beta 1 to exert renal-protect anti-tumor effect;It modulate calcium/phosphorus metabolism as a co-receptor of FGF-23. The regulation of Klotho gene expression is very complex, but because of its anti-aging effect in various systems, more and more attention is paid to it.