国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
10期
1879-1881
,共3页
李上%于晶%谢连永%郭纯刚
李上%于晶%謝連永%郭純剛
리상%우정%사련영%곽순강
获得性免疫缺陷综合征%人类免疫缺陷病毒%巨细胞病毒性视网膜炎%光学相干断层扫描
穫得性免疫缺陷綜閤徵%人類免疫缺陷病毒%巨細胞病毒性視網膜炎%光學相榦斷層掃描
획득성면역결함종합정%인류면역결함병독%거세포병독성시망막염%광학상간단층소묘
acquire immunodeficiency syndrome%human immunodeficiency virus%cytomegalovirus retinitis%optical coherence tomography
目的：评价获得性免疫缺陷综合征( AIDS )患者黄斑区视网膜厚度的变化。<br> 方法：对我院人类免疫缺陷病毒( HIV )阳性住院患者38例64眼进行研究。根据CD4计数以及是否发生巨细胞病毒性视网膜炎( CMVR)分为3组,A组16例32眼,CD4计数<50个/μL,未发生CMVR；B组10例20眼CD4计数>50个/μL,未发生CMVR；C组12例12眼CD4计数<50个/μL,伴有CMVR。以未感染HIV病毒的正常人10例20眼作为正常对照组,设为D组。采用光学相干断层扫描(OCT)对以黄斑为中心1mm直径范围内的视网膜厚度进行分析。<br> 结果：A组黄斑中心区域的平均视网膜厚度是254.03±15.63μm,B组黄斑中心区域的平均视网膜厚度是263.11±17.12μm,C组黄斑中心区域的平均视网膜厚度是304.50±50.62μm,D组黄斑中心区域的平均视网膜厚度是257.64±8.54μm。各组黄斑中心的视网膜厚度比较,总体上有统计学差异(F=12.933,P=0.000)。 CMVR组黄斑中心区域视网膜增厚,与各组组间比较有统计学差异(P=0.000)。结论：CMVR可以导致黄斑部视网膜的结构和功能损伤,严重影响患者的视功能。早期通过OCT检查黄斑区形态结构,有助于了解CMVR病情的进展和预后。
目的：評價穫得性免疫缺陷綜閤徵( AIDS )患者黃斑區視網膜厚度的變化。<br> 方法：對我院人類免疫缺陷病毒( HIV )暘性住院患者38例64眼進行研究。根據CD4計數以及是否髮生巨細胞病毒性視網膜炎( CMVR)分為3組,A組16例32眼,CD4計數<50箇/μL,未髮生CMVR；B組10例20眼CD4計數>50箇/μL,未髮生CMVR；C組12例12眼CD4計數<50箇/μL,伴有CMVR。以未感染HIV病毒的正常人10例20眼作為正常對照組,設為D組。採用光學相榦斷層掃描(OCT)對以黃斑為中心1mm直徑範圍內的視網膜厚度進行分析。<br> 結果：A組黃斑中心區域的平均視網膜厚度是254.03±15.63μm,B組黃斑中心區域的平均視網膜厚度是263.11±17.12μm,C組黃斑中心區域的平均視網膜厚度是304.50±50.62μm,D組黃斑中心區域的平均視網膜厚度是257.64±8.54μm。各組黃斑中心的視網膜厚度比較,總體上有統計學差異(F=12.933,P=0.000)。 CMVR組黃斑中心區域視網膜增厚,與各組組間比較有統計學差異(P=0.000)。結論：CMVR可以導緻黃斑部視網膜的結構和功能損傷,嚴重影響患者的視功能。早期通過OCT檢查黃斑區形態結構,有助于瞭解CMVR病情的進展和預後。
목적：평개획득성면역결함종합정( AIDS )환자황반구시망막후도적변화。<br> 방법：대아원인류면역결함병독( HIV )양성주원환자38례64안진행연구。근거CD4계수이급시부발생거세포병독성시망막염( CMVR)분위3조,A조16례32안,CD4계수<50개/μL,미발생CMVR；B조10례20안CD4계수>50개/μL,미발생CMVR；C조12례12안CD4계수<50개/μL,반유CMVR。이미감염HIV병독적정상인10례20안작위정상대조조,설위D조。채용광학상간단층소묘(OCT)대이황반위중심1mm직경범위내적시망막후도진행분석。<br> 결과：A조황반중심구역적평균시망막후도시254.03±15.63μm,B조황반중심구역적평균시망막후도시263.11±17.12μm,C조황반중심구역적평균시망막후도시304.50±50.62μm,D조황반중심구역적평균시망막후도시257.64±8.54μm。각조황반중심적시망막후도비교,총체상유통계학차이(F=12.933,P=0.000)。 CMVR조황반중심구역시망막증후,여각조조간비교유통계학차이(P=0.000)。결론：CMVR가이도치황반부시망막적결구화공능손상,엄중영향환자적시공능。조기통과OCT검사황반구형태결구,유조우료해CMVR병정적진전화예후。
AIM: To assess the changes of macular thickness of acquire immunodeficiency syndrome ( AIDS) patients. <br> METHODS:The study based on the data analysis of 38 human immunodeficiency virus ( HIV ) positive patients ( 64 eyes ) . According to CD4 count and whether cytomegalovirus retinitis ( CMVR) happened, the patients were divided into 3 groups. Group A included 16 patients (32 eyes), in which CD4 count was < 50cells/μL and CMVR did not happen. Group B included 10 patients ( 20 eyes), in which CD4 count was>50cells/μL and CMVR did not happen. Group C included 12 patients (12 eyes), in which CD4 count was < 50cells/μL and CMVR just happened. Group D included 10 healthy people ( 20 eyes ) , as normal control group. By using optical coherence tomography ( OCT ) , thickness of retina along with a 1mm diameter circle centered on macular was evaluated. <br> RESULTS:The mean foveal thicknesses in groups A, B, C and D were 254. 03±15. 63μm, 263. 11±17. 12μm, 304. 50±50. 62μm and 257. 64±8. 54μm in order. Compared with foveal thickness in each group, there were significant differences in general (F=12. 933, P=0. 000). The mean foveal thickness in groups CMVR increased, which was of significant difference (P= 0. 000), compared with other groups. <br> CONCLUSION: CMVR can impair the structure and function of macular, which then seriously affects the visual function of patients. It's helpful to understand the progress and prognosis of CMVR disease by observing macular structure with OCT in early time.
