中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2013年
7期
664-667
,共4页
刘斌%何明光%黄圣松%殷秋霞%丁小虎
劉斌%何明光%黃聖鬆%慇鞦霞%丁小虎
류빈%하명광%황골송%은추하%정소호
生物学测量%视盘/参数,结构%视网膜断层扫描/方法%海德堡视网膜断层扫描仪%成人%性别
生物學測量%視盤/參數,結構%視網膜斷層掃描/方法%海德堡視網膜斷層掃描儀%成人%性彆
생물학측량%시반/삼수,결구%시망막단층소묘/방법%해덕보시망막단층소묘의%성인%성별
Bio-metrics%Optic nerve head/parameter,structure%Tomography/method%Heidelberg retinal tomograph%Adult%Gender
背景 正常成人视盘的盘沿宽度符合下方(I)≥上方(S)≥鼻侧(N)≥颞侧(T)的ISNT原则,通过对海德堡视网膜断层扫描仪(HRT)视盘结构参数的分析可以了解ISNT原则是否适用于其他视盘结构参数. 目的 探讨中国健康成人视盘结构参数在不同象限中的分布规律和特征.方法 采用横断面研究设计,选取2006年6月至2011年8月在中山大学中山眼科中心参加广州双生子研究的家长作为受试者.所有受试者均完成视力、裂隙灯显微镜、直接检眼镜、自动验光仪和HRT-Ⅲ检查,受试者右眼的测量数据纳入研究,对不同性别间各参数测量值的差异、视盘不同象限间测量指标的差异和特征进行分析,采用单因素方差分析比较不同象限的HRT测量值,用Bonferroni法进一步进行多重检验.结果 纳入研究1672人1672眼,其中男759人,女913人；平均年龄(41.8±5.3)岁.检测结果显示,视盘下方与上方的视盘面积(DA)、鼻侧与颞侧的DA测量值差异均无统计学意义(P＞0.05)；视盘上方与鼻侧的盘沿面积(RA)以及视盘下方、上方和鼻侧的盘沿容积(RV)差异均无统计学意义(P＞0.05),其他HRT视盘结构参数,如视杯面积(CA)、杯盘面积比(C/DAR)、视杯容积(CV)、平均视杯深度(MCD)、最大视杯深度(MxCD)、轮廓线高度变化(HVC)、视杯形态测量(CSM)、平均视网膜神经纤维层厚度(mRNFLT)和视网膜神经纤维层横断面积(RNFLcsa)在不同象限间的差异均有统计学意义(P＜0.001),但只有DA和RA的局部差异符合ISNT的原则.男性的DA、CA、C/DAR、CV、MCD、MxCD测量值较大,而RV、HVC mRNFLT和RNFLcsa测量值低于女性受试者,但这些差异均＜0.1,平均差异最大的指标是DA和CA,均为0.07 mm2. 结论 中国健康成人眼HRT视盘结构参数在不同象限有不同的分布特征,多数结构参数在视盘上方、下方测量值大于鼻侧、颞侧,仅有DA和RA的局部差异符合ISNT原则.多数结构参数在性别之间有很小的差异,但不影响对整体人群视盘结构的评价.
揹景 正常成人視盤的盤沿寬度符閤下方(I)≥上方(S)≥鼻側(N)≥顳側(T)的ISNT原則,通過對海德堡視網膜斷層掃描儀(HRT)視盤結構參數的分析可以瞭解ISNT原則是否適用于其他視盤結構參數. 目的 探討中國健康成人視盤結構參數在不同象限中的分佈規律和特徵.方法 採用橫斷麵研究設計,選取2006年6月至2011年8月在中山大學中山眼科中心參加廣州雙生子研究的傢長作為受試者.所有受試者均完成視力、裂隙燈顯微鏡、直接檢眼鏡、自動驗光儀和HRT-Ⅲ檢查,受試者右眼的測量數據納入研究,對不同性彆間各參數測量值的差異、視盤不同象限間測量指標的差異和特徵進行分析,採用單因素方差分析比較不同象限的HRT測量值,用Bonferroni法進一步進行多重檢驗.結果 納入研究1672人1672眼,其中男759人,女913人；平均年齡(41.8±5.3)歲.檢測結果顯示,視盤下方與上方的視盤麵積(DA)、鼻側與顳側的DA測量值差異均無統計學意義(P＞0.05)；視盤上方與鼻側的盤沿麵積(RA)以及視盤下方、上方和鼻側的盤沿容積(RV)差異均無統計學意義(P＞0.05),其他HRT視盤結構參數,如視杯麵積(CA)、杯盤麵積比(C/DAR)、視杯容積(CV)、平均視杯深度(MCD)、最大視杯深度(MxCD)、輪廓線高度變化(HVC)、視杯形態測量(CSM)、平均視網膜神經纖維層厚度(mRNFLT)和視網膜神經纖維層橫斷麵積(RNFLcsa)在不同象限間的差異均有統計學意義(P＜0.001),但隻有DA和RA的跼部差異符閤ISNT的原則.男性的DA、CA、C/DAR、CV、MCD、MxCD測量值較大,而RV、HVC mRNFLT和RNFLcsa測量值低于女性受試者,但這些差異均＜0.1,平均差異最大的指標是DA和CA,均為0.07 mm2. 結論 中國健康成人眼HRT視盤結構參數在不同象限有不同的分佈特徵,多數結構參數在視盤上方、下方測量值大于鼻側、顳側,僅有DA和RA的跼部差異符閤ISNT原則.多數結構參數在性彆之間有很小的差異,但不影響對整體人群視盤結構的評價.
배경 정상성인시반적반연관도부합하방(I)≥상방(S)≥비측(N)≥섭측(T)적ISNT원칙,통과대해덕보시망막단층소묘의(HRT)시반결구삼수적분석가이료해ISNT원칙시부괄용우기타시반결구삼수. 목적 탐토중국건강성인시반결구삼수재불동상한중적분포규률화특정.방법 채용횡단면연구설계,선취2006년6월지2011년8월재중산대학중산안과중심삼가엄주쌍생자연구적가장작위수시자.소유수시자균완성시력、렬극등현미경、직접검안경、자동험광의화HRT-Ⅲ검사,수시자우안적측량수거납입연구,대불동성별간각삼수측량치적차이、시반불동상한간측량지표적차이화특정진행분석,채용단인소방차분석비교불동상한적HRT측량치,용Bonferroni법진일보진행다중검험.결과 납입연구1672인1672안,기중남759인,녀913인；평균년령(41.8±5.3)세.검측결과현시,시반하방여상방적시반면적(DA)、비측여섭측적DA측량치차이균무통계학의의(P＞0.05)；시반상방여비측적반연면적(RA)이급시반하방、상방화비측적반연용적(RV)차이균무통계학의의(P＞0.05),기타HRT시반결구삼수,여시배면적(CA)、배반면적비(C/DAR)、시배용적(CV)、평균시배심도(MCD)、최대시배심도(MxCD)、륜곽선고도변화(HVC)、시배형태측량(CSM)、평균시망막신경섬유층후도(mRNFLT)화시망막신경섬유층횡단면적(RNFLcsa)재불동상한간적차이균유통계학의의(P＜0.001),단지유DA화RA적국부차이부합ISNT적원칙.남성적DA、CA、C/DAR、CV、MCD、MxCD측량치교대,이RV、HVC mRNFLT화RNFLcsa측량치저우녀성수시자,단저사차이균＜0.1,평균차이최대적지표시DA화CA,균위0.07 mm2. 결론 중국건강성인안HRT시반결구삼수재불동상한유불동적분포특정,다수결구삼수재시반상방、하방측량치대우비측、섭측,부유DA화RA적국부차이부합ISNT원칙.다수결구삼수재성별지간유흔소적차이,단불영향대정체인군시반결구적평개.
Background Normal adult optic disc rim width follows inferior ≥ superior ≥ nasal ≥ temporal (ISNT) rule.Analysis of the optic disc structural parameters with Heidelberg retina tomograph (HRT) can understand whether ISNT principle is suitable to other optic disc structure parameters.Objective This study was to investigate the characteristics of optic nerve head structure parameters in normal Chinese adults.Methods The parents of twins who participated Guangzhou Twin Eye Study were enrolled in Zhongshan Ophthalmic Center from 2006 June to 2011 August.All subjects received the routine eye examinations,including visual acuity,slit lamp microscope,direct ophthalmoscope examination,auto-refraction examination and HRT Ⅲ examination.All data from the right eyes were collected and analyzed.HRT values from different quadrants of optical nerve head were compared with one-way analysis of variance,and the multiple comparison between quadrants was carried out by Bonferroni test.The differences of optical nerve head parameters in different gender were analyzed using independent sample t test and Bland-Altman test.Results In this study,1672 eyes of 1672 subjects were included,with the 759 male and 913 female persons and average age of (41.8±5.3)years.No significant differences were seen in the disc area (DA)between the superior and inferior,as well as the nasal and temporal quadrants among the subjects (P＞0.05).In addition,there were not significantly different in the rim area (RA) between the superior and nasal disc as well as the rim volume (RV) among the inferior,superior and nasal disc (P＞O.05).However,significant differences were found in the cup area (CA),cup/disk area ratio (C/DAR),cup volume (CV),mean cupdepth (MCD),maximum cup depth (MxCD),height variation contour (HVC),cup shape measure (CSM),mean retinal nerve fiber layer thickness (mRNFLT) and retinal nerve fiber layer cross section area (RNFLcsa) among the different quadrants (P＜0.001).The local differences from only DA and RA complied with an ordination of the ISNT rule.The values of DA,CA,C/DAR,CV,MCD,MxCD from male individuals were higher,but those of the RV,HVC,mRNFLT RNFLcsa were lower in comparison with female individuals.Nevertheless,all the differences were ＜ 0.1 with a maximal mean difference in DA and CA (both 0.07 mm2).Conclusions The optical nerve head configurations measured by HRT have different distributing characteristics in four quadrants in normal adults.Most parameters show the higher values in the inferior and superior than those in nasal and temporal of disc,but DA and RA meet ISNT rule.The differences of most parameters between male and female subjects can be ignored.
