CAJ | 학술논문

目的：研究限制性和积极性液体复苏对未控制的出血性休克（uncontrolled hemorrhagic shock ，uHs）大鼠肠黏膜机械屏障功能障碍的影响。方法36只sd大鼠建立uHs模型，随机分成对照组（a组）、限制性复苏组（B组）、积极复苏组(c组)。模拟创伤救治过程，a组大鼠未行液体复苏，B、c组进行不同方法液体复苏，5小时后观察各组进行小肠组织病理学改变和电镜超微结构。结果 a组病理学评分高于B、c组，B组低于c组（P<0.05），电镜下肠黏膜观察：B组大鼠肠上皮细胞、微绒毛、线粒体、细胞核等受损程度较c组轻。结论 uHs出现严重肠黏膜机械屏障破坏，限制性液体复苏较快速积极复苏更能减轻实验性uHs大鼠肠黏膜的病理损伤,可能对uHs大鼠肠黏膜机械屏障保护更有益。
목적：연구한제성화적겁성액체복소대미공제적출혈성휴극（uncontrolled hemorrhagic shock ，uHs）대서장점막궤계병장공능장애적영향。방법36지sd대서건립uHs모형，수궤분성대조조（a조）、한제성복소조（B조）、적겁복소조(c조)。모의창상구치과정，a조대서미행액체복소，B、c조진행불동방법액체복소，5소시후관찰각조진행소장조직병이학개변화전경초미결구。결과 a조병이학평분고우B、c조，B조저우c조（P<0.05），전경하장점막관찰：B조대서장상피세포、미융모、선립체、세포핵등수손정도교c조경。결론 uHs출현엄중장점막궤계병장파배，한제성액체복소교쾌속적겁복소경능감경실험성uHs대서장점막적병리손상,가능대uHs대서장점막궤계병장보호경유익。
Objective To study the effects of limited fluid resuscitation and aggressive fluid resuscitation on intestinal epithelium mechanical barrier dysfunction in rats with uncontrolled hemorrhagic shock. Method models of 36 sd rats with uncontrolled hemorrhagic shock were installed and divided randomly into 3 groups:(a)control group,(B) limited fluid resuscitation group,(c) aggressive fluid resuscitation group.fluid resuscitation was not used in a group, while different measures of fluid resuscitation in B and c group, To evaluate histopathology scoring and observe ultrastructure of intestinal mucosal by electron microscope all of rats after 5h.Result The histopathology scoring of a group is higher significantly than B and c group. The damages of intestinal epithelium cells, microvilli, mitochondria, nuclear in B group were lighter than those in group c under observing electron microscope. Conclusion uHs lead to serious damages in intestinal epithelium mechanical barrier, there were few damages by applying the limited fluid resuscitation than that by aggressive fluid resuscitation, and it was benefical for intestinal Epithelium mechanical Barrier in rats with uHs.