CAJ | 학술논문

目的：建立鼻咽解毒胶囊一测多评的含量测定方法，验证该方法在鼻咽解毒胶囊质量控制中应用的可行性和准确性。方法以盐酸小檗碱为内参物，建立盐酸小檗碱与黄芩苷的相对校正因子，同时根据盐酸小檗碱与巴马汀、黄连碱、表小檗碱的内在函数关系，应用于含量测定，建立其一测多评法的多指标质量控制方法。结果建立了鼻咽解毒胶囊中多种成分一测多评法方法学的考察模式。结论以盐酸小檗碱、巴马汀、黄连碱、表小檗碱和黄芩苷为指标，采用一测多评法控制鼻咽解毒胶囊质量可行。
목적：건립비인해독효낭일측다평적함량측정방법，험증해방법재비인해독효낭질량공제중응용적가행성화준학성。방법이염산소벽감위내삼물，건립염산소벽감여황금감적상대교정인자，동시근거염산소벽감여파마정、황련감、표소벽감적내재함수관계，응용우함량측정，건립기일측다평법적다지표질량공제방법。결과건립료비인해독효낭중다충성분일측다평법방법학적고찰모식。결론이염산소벽감、파마정、황련감、표소벽감화황금감위지표，채용일측다평법공제비인해독효낭질량가행。
Objective To establish an QAMS method for determining the contents of Biyan Jiedu Capsules, and examine its feasibility and accuracy applicability in the quality control of Biyan Jiedu Capsules. Methods The content of berberine hydrochloride was adopted as the internal reference, to establish the relative correction factors of berberine hydrochloride and baicalin, and establishing berberine hydrochloride intrinsic function relation with other compositions palmatine, coptisine and epiberberine used in determination was established by control method of QAMS. Results The multi-index quality control method of QAMS was establish in Biyan Jiedu Capsules. Conclusion The QAMS can be used for quality control of berberine hydrochloride, palmatine, coptisine, epiberberinein and baicalin in Biyan Jiedu Capsules.