疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
4期
365-367
,共3页
陈娜%陆连生%宋巧%杨香敏%卢海丽%史万英
陳娜%陸連生%宋巧%楊香敏%盧海麗%史萬英
진나%륙련생%송교%양향민%로해려%사만영
前列地尔%脑梗死,腔隙性%糖尿病%甲襞微循环
前列地爾%腦梗死,腔隙性%糖尿病%甲襞微循環
전렬지이%뇌경사,강극성%당뇨병%갑벽미순배
Alprostadil%Infarction,lacunar%Diabetes%Nail fold microcirculation
目的:探讨前列地尔治疗糖尿病腔隙性脑梗死患者的临床疗效及对血糖、纤维蛋白原及甲襞微循环的影响。方法糖尿病腔隙性脑梗死患者95例随机分为治疗组48例和对照组47例。2组均以常规治疗为基础,对照组加用舒血宁治疗,观察组加用前列地尔治疗,治疗14 d后比较2组临床疗效、美国国立卫生院神经功能缺损评分(NIHSS)、血浆纤维蛋白原(Fg)、高敏C反应蛋白(hs-CRP)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)及甲襞微循环变化。结果治疗组临床疗效明显高于对照组(91.6% vs 78.8%, P <0.05)。2组NIHSS评分均改善,且治疗组优于对照组( P <0.01, P <0.05)。2组Fg、hs-CRP、FPG及微循环指标均改善,且治疗组较对照组均明显好转( P <0.05, P <0.01)。结论糖尿病腔隙性脑梗死患者应用前列地尔能够显著改善临床疗效,提高其神经功能,且无明显不良反应,值得推广应用。
目的:探討前列地爾治療糖尿病腔隙性腦梗死患者的臨床療效及對血糖、纖維蛋白原及甲襞微循環的影響。方法糖尿病腔隙性腦梗死患者95例隨機分為治療組48例和對照組47例。2組均以常規治療為基礎,對照組加用舒血寧治療,觀察組加用前列地爾治療,治療14 d後比較2組臨床療效、美國國立衛生院神經功能缺損評分(NIHSS)、血漿纖維蛋白原(Fg)、高敏C反應蛋白(hs-CRP)、空腹血糖(FPG)、糖化血紅蛋白(HbA1c)及甲襞微循環變化。結果治療組臨床療效明顯高于對照組(91.6% vs 78.8%, P <0.05)。2組NIHSS評分均改善,且治療組優于對照組( P <0.01, P <0.05)。2組Fg、hs-CRP、FPG及微循環指標均改善,且治療組較對照組均明顯好轉( P <0.05, P <0.01)。結論糖尿病腔隙性腦梗死患者應用前列地爾能夠顯著改善臨床療效,提高其神經功能,且無明顯不良反應,值得推廣應用。
목적:탐토전렬지이치료당뇨병강극성뇌경사환자적림상료효급대혈당、섬유단백원급갑벽미순배적영향。방법당뇨병강극성뇌경사환자95례수궤분위치료조48례화대조조47례。2조균이상규치료위기출,대조조가용서혈저치료,관찰조가용전렬지이치료,치료14 d후비교2조림상료효、미국국립위생원신경공능결손평분(NIHSS)、혈장섬유단백원(Fg)、고민C반응단백(hs-CRP)、공복혈당(FPG)、당화혈홍단백(HbA1c)급갑벽미순배변화。결과치료조림상료효명현고우대조조(91.6% vs 78.8%, P <0.05)。2조NIHSS평분균개선,차치료조우우대조조( P <0.01, P <0.05)。2조Fg、hs-CRP、FPG급미순배지표균개선,차치료조교대조조균명현호전( P <0.05, P <0.01)。결론당뇨병강극성뇌경사환자응용전렬지이능구현저개선림상료효,제고기신경공능,차무명현불량반응,치득추엄응용。
To evaluate the clinical efficacy of alprostadil in treatment of diabetic patients with lacunar infarction and various indicators'changes .Methods Diabetic patients with lacunar infarction 95 cases were randomly divided into treatment group (48 cases ) and control group ( 47 cases ).2 groups are based on conventional therapy , the control group plus Shuxuening treatment, observation group were treated with alprostadil treatment , clinical efficacy compared between the two groups 14 d after treatment , the U.S.National Institutes of Health neurologic deficit score ( NIHSS ) , plasma fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), fasting plasma glucose (FPG), glycated hemoglobin (HbA1c) and nail fold microcirculation were observed .Results Clinical efficacy of the treatment group was significantly higher (91.6% vs. 78.8%, P <0.05).2 groups NIHSS scores were improved , and the treatment group better than the control group ( P <0.01, P <0.05).2 groups'Fg, hs-CRP, FPG and microcirculation indicators are improved , and the treatment group were significantly better than the control group ( P <0.05, P <0.01).Conclusion Alprostadil can significantly improve the clin-ical efficacy and improve neurological function in diabetic patients with lacunar infarction , and no significant adverse reactions were observed , it can be widely applied .