CAJ | 학술논문

目的：观察脐血干细胞移植治疗缺血性心脏病的临床疗效和安全性。方法30例伴有冠状动脉多支病变经一般药物治疗效果欠佳、不适合行介入治疗和冠状动脉搭桥手术的缺血性心脏病患者，采用人脐血干细胞经冠状动脉造影介入移植治疗。脐血干细胞治疗前、术后3月及6月分别采用超声心动图评价心功能，行SF-36健康量表评价生活质量，并观察患者临床症状及体征的改善情况及不良反应。结果脐血干细胞治疗后1周26例患者的临床症状明显改善，术后3月及6月左室舒张末容量和左室收缩末容量均较术前显著减小，左室射血分数较术前显著提高（ P ＜0 k．05， P ＜0．01）。 SF-36健康量表评分治疗术后3个月、6个月较治疗前身体功能、运动限制及总体健康评分均有显著提高（ P ＜0．05， P ＜0．01），治疗中及术后随访6个月未观察到与治疗相关的不良反应。结论脐血干细胞经冠状动脉介入治疗缺血性心脏病，短期内可以改善患者的临床症状和心功能，是一种安全有效的治疗选择。
목적：관찰제혈간세포이식치료결혈성심장병적림상료효화안전성。방법30례반유관상동맥다지병변경일반약물치료효과흠가、불괄합행개입치료화관상동맥탑교수술적결혈성심장병환자，채용인제혈간세포경관상동맥조영개입이식치료。제혈간세포치료전、술후3월급6월분별채용초성심동도평개심공능，행SF-36건강량표평개생활질량，병관찰환자림상증상급체정적개선정황급불량반응。결과제혈간세포치료후1주26례환자적림상증상명현개선，술후3월급6월좌실서장말용량화좌실수축말용량균교술전현저감소，좌실사혈분수교술전현저제고（ P ＜0 k．05， P ＜0．01）。 SF-36건강량표평분치료술후3개월、6개월교치료전신체공능、운동한제급총체건강평분균유현저제고（ P ＜0．05， P ＜0．01），치료중급술후수방6개월미관찰도여치료상관적불량반응。결론제혈간세포경관상동맥개입치료결혈성심장병，단기내가이개선환자적림상증상화심공능，시일충안전유효적치료선택。
Objective To observe the clinical efficacy and safety of cord blood stem cell transplantation for ischemic heart disease treatment .Methods Thirty cases of patients with ischemic heart disease with coronary multi-vessel disease after drug treatment is generally ineffective , not suitable for interventional therapy and coronary artery bypass surgery , they received treatment of using of stem cells from human cord blood through the coronary interventional angiography transplantation therapy . Review the ECG and laboratory indicators , observed treatment safety , echocardiographic evaluation of cardiac function , and performed SF-36 Health Questionnaire to evaluate the quality of life and clinical symptoms of patients and improvement of signs and adverse reactions before cord blood stem cells treatment , 3 and 6 months after treatment , respectively .Results After one week of umbilical cord blood stem cell therapy , clinical symptoms of 26 patients improved significantly , 3 and 6 months after surgery, left ventricular end-diastolic volume and left ventricular end-systolic significantly reduced than before therapy .Left ventricular ejection fraction was significantly improved compared with the preoperative ( P <0.05, P <0.01).SF 36 health scores revealed that , 3 months and 6 months after treatment , compared with pre-treatment physical function , exercise restric-tions and general health scores were significantly increased ( P <0.05, P <0.01), and after treatment, patients were fol-lowed up for 6 months, no treatment-related adverse reactions were observed .Conclusion Cord blood stem cells via coronary intervention can improve clinical symptoms and cardiac function in patients with ischemic heart disease in short -term, is a safe and effective treatment options .