CAJ | 학술논문

目的：探讨神经节苷脂（G M1）治疗新生儿缺氧缺血性脑病（H I E）的疗效。方法将36例中重度患儿中15例按照三维持、三对症原则治疗；21例在常规治疗的基础上采用GM1治疗。2个疗程后，疗效评定。结果 GM1治疗组显效率61.9%，总有效率90.5%，和常规治疗组比较，差异具有显著性（P＜0.05）。结论在常规治疗HIE的基础上加用GM1，神经功能恢复较快，致残率低，无不良反应，值得临床推广使用。
목적：탐토신경절감지（G M1）치료신생인결양결혈성뇌병（H I E）적료효。방법장36례중중도환인중15례안조삼유지、삼대증원칙치료；21례재상규치료적기출상채용GM1치료。2개료정후，료효평정。결과 GM1치료조현효솔61.9%，총유효솔90.5%，화상규치료조비교，차이구유현저성（P＜0.05）。결론재상규치료HIE적기출상가용GM1，신경공능회복교쾌，치잔솔저，무불량반응，치득림상추엄사용。
Objective: To investigate the effect of ganglioside (GM1) in treatment of neonatal hypoxic ischemic encephalopathy (HIE). Methods: 15 cases in 36 patients with moderate to severe HIE were treated under the principles of the three maintaining and three symptomatic treatment; 21 cases were treated with GM1 on the basis of routine treatment. After 2 courses, fhe efficacy was evaluated. Results: Good efficiency rate in GM1 treatment group was 61.9% with 90.5% total efficiency, compared with the conventional treatment group, the difference was significant(P<0.05). Conclusion: Using GM1 on the basis of conventional treatment of HIE,recovery Of nerve function was rapid, morbidity was low, there was no adverse reactions, and woflhy of clinical use.