CAJ | 학술논문

目的：探讨血清降钙素原(PCT)联合C-反应蛋白(CRP)测定在支气管哮喘急性发作期并细菌感染中的诊断价值。方法本研究观察87例住院支气管哮喘急性发作期患者，入院当天治疗前测定血清PCT及CRP水平，并进行痰液细菌学培养和胸部影像学等检查。根据临床特征、实验室、痰液细菌学培养以及影像学检查结果，将支气管哮喘急性发作期患者分为细菌感染组和非细菌感染组。比较两组患者治疗前血清PCT、CRP水平及治疗后变化。结果在急性加重期，细菌感染组血清PCT及CRP水平显著高于非细菌感染组(P＜0.01)。治疗后两组患者血清PCT及CRP水平比较差异无统计学意义(P＞0.05)。结论血清PCT联合CRP测定可协助判断支气管哮喘急性发作期患者是否合并细菌感染。血清PCT、CRP水平高低可作为是否使用抗菌药物的参考依据。
목적：탐토혈청강개소원(PCT)연합C-반응단백(CRP)측정재지기관효천급성발작기병세균감염중적진단개치。방법본연구관찰87례주원지기관효천급성발작기환자，입원당천치료전측정혈청PCT급CRP수평，병진행담액세균학배양화흉부영상학등검사。근거림상특정、실험실、담액세균학배양이급영상학검사결과，장지기관효천급성발작기환자분위세균감염조화비세균감염조。비교량조환자치료전혈청PCT、CRP수평급치료후변화。결과재급성가중기，세균감염조혈청PCT급CRP수평현저고우비세균감염조(P＜0.01)。치료후량조환자혈청PCT급CRP수평비교차이무통계학의의(P＞0.05)。결론혈청PCT연합CRP측정가협조판단지기관효천급성발작기환자시부합병세균감염。혈청PCT、CRP수평고저가작위시부사용항균약물적삼고의거。
Objective To explore the significance of serum procalcitonin (PCT) and C- reactive protein (CRP) determination in acute exacerbation of bronchial asthma and diagnostic value of bacterial infections. Methods In this study, 87 cases of hospitalized patients with acute exacerbation of bronchial asthma, on the day of admission before treatment the serum PCT and CRP levels, and the sputum bacteriology and chest radiographic examination. According to the clinical features, laboratory, sputum bacterial culture and imaging findings, acute bronchial asthma patients were divided into group and non bacterial infection group bacterial infection. Comparison of two groups of patients before treatment the serum PCT, CRP levels and changes after treatment. Results in acute exacerbation of bacterial infection group, serum PCT and CRP levels were significantly higher than those in non bacterial infection group (P < 0.01). No statistical y significant after treatment, compared two groups of patients with serum PCT and CRP level difference (P > 0.05). Conclusion The serum PCT and CRP measurement can help determine whether patients with acute exacerbation of bronchial asthma complicated with bacterial infection. Serum PCT, CRP level may be used as an antibacterial drug reference.