CAJ | 학술논문

目的：观察替吉奥胶囊联合奥沙利铂治疗老年晚期食管癌的临床疗效和不良反应。方法63例晚期食管癌患者,年龄均>65岁,采用替吉奥胶囊联合奥沙利铂方案治疗,21 d为一周期,治疗2个周期后评价疗效及不良反应。结果63例患者中CR 8例, PR 23例, SD 14例, PD 18例,有效率RR为49.2%,中位生存时间10.4个月。毒副反应主要为感觉神经毒性、消化道反应和血液学毒性。结论替吉奥胶囊联合奥沙利铂治疗老年晚期食管癌疗效较好,不良反应轻,患者耐受性好,值得临床推广应用。
목적：관찰체길오효낭연합오사리박치료노년만기식관암적림상료효화불량반응。방법63례만기식관암환자,년령균>65세,채용체길오효낭연합오사리박방안치료,21 d위일주기,치료2개주기후평개료효급불량반응。결과63례환자중CR 8례, PR 23례, SD 14례, PD 18례,유효솔RR위49.2%,중위생존시간10.4개월。독부반응주요위감각신경독성、소화도반응화혈액학독성。결론체길오효낭연합오사리박치료노년만기식관암료효교호,불량반응경,환자내수성호,치득림상추엄응용。
Objective To observe the efficacy and side effects of S-1 and oxaliplantin in the treatment of old advanced esophageal cancer patients. Methods 63 cases of advanced esophageal cancer, all were older than 65, treated with S-1 and oxaliplantin, the cycle was repeated every 21 days, after two consecutive treatment, the short term efficacy and adverse effects was observed. Results Among the 63 patients, 8 paients were CR, 23 patients PR, 14 SD, 18 PD, the overall response rate was 49. 2%, the middle survival time was 10.4 months. Major side-effects were neurosensory toxicity, gastrointestinal disturbance, and hematological toxicities. Conclusion S-1 and Oxaliplantin is effective for the old advanced esophageal cancer patients, and the toxicity and side-effects are tolerable.