CAJ | 학술논문

目的：比较高度近视患者在准分子激光上皮下角膜磨镶术（ LASEK）中分别使用不同浓度丝裂霉素C（MMC）的效果。方法对52例（104只眼）行LASEK的高度近视患者，分成A、B、C三组，三组术中分别使用0．005％、0．01％、0．02％浓度的MMC棉片覆盖激光切削后的基质床。观察术后裸眼视力、角膜上皮愈合时间及角膜上皮下混浊（ Haze ）的形成情况。结果在术后裸眼视力和Haze形成方面：A组与B组、C组分别比较差异均有统计学意义（ P ＜0．05）；B组与C组比较差异无统计学意义（ P ＞0．05）；在角膜上皮愈合时间方面：C组与A组、B组分别比较差异均有统计学意义（ P ＜0．05）；A组与B组比较差异无统计学意义（ P ＞0．05）。结论 LASEK术中采用0．01％MMC可以有效抑制Haze的形成，恢复术后良好视力，且不会明显延迟角膜上皮愈合。
목적：비교고도근시환자재준분자격광상피하각막마양술（ LASEK）중분별사용불동농도사렬매소C（MMC）적효과。방법대52례（104지안）행LASEK적고도근시환자，분성A、B、C삼조，삼조술중분별사용0．005％、0．01％、0．02％농도적MMC면편복개격광절삭후적기질상。관찰술후라안시력、각막상피유합시간급각막상피하혼탁（ Haze ）적형성정황。결과재술후라안시력화Haze형성방면：A조여B조、C조분별비교차이균유통계학의의（ P ＜0．05）；B조여C조비교차이무통계학의의（ P ＞0．05）；재각막상피유합시간방면：C조여A조、B조분별비교차이균유통계학의의（ P ＜0．05）；A조여B조비교차이무통계학의의（ P ＞0．05）。결론 LASEK술중채용0．01％MMC가이유효억제Haze적형성，회복술후량호시력，차불회명현연지각막상피유합。
Objective To compare the effects of mitomycin C ( MMC) of different concentrations on laser-assisted sub-epithelial keratectomy (LASEK) in high myopia eyes.Methods Totally 52 patients (104 eyes) with high myopia re-ceived LASEK.Subjects were randomly assigned into three groups (A, B, and C).Each group of patients were treated with 0.005%, 0.01%, or 0.02%MMC to cover the corneal stromal bed after laser ablation .Then we observed uncorrect-ed visual acuity , corneal epithelial healing time and Haze .Results There was statistically significant difference ( P <0. 05) in visual acuity and rate of corneal haze between group A and group B or group C patients , but there was no significant difference between group B and group C .Regarding corneal epithelial healing time , there was significant difference ( P <0.05) between group C and A group or group B , but there was no significant difference between group A and group B . Conclusions 0.01%MMC effectively inhibits haze formation , restores visual acuity better , and does not significantly de-lay corneal epithelial healing .