CAJ | 학술논문

目的探讨润兴牙龈炎冲洗器和洁悠神用于鼻咽癌放射性口腔黏膜炎的疗效,并分析其影响因素.方法将92例鼻咽癌患者随机分为研究组与对照组各46例,研究组采用润兴牙龈炎冲洗器和洁悠神长效抗菌材料进行口腔处理,对照组行常规口腔护理.结果研究组40例完成了2个周期的化疗,对照组26例完成了2个周期的化疗(x2 =10.51,P=0.001).研究组3例患者因口腔黏膜反应而延迟治疗,对照组共有13例患者延迟了至少3d以上(x2=7.57,P=0.006).研究组40例为Ⅰ～Ⅱ级口腔黏膜反应,6例出现Ⅲ级口腔黏膜反应；对照组23例Ⅰ～Ⅱ级口腔黏膜反应,23例Ⅲ～Ⅳ级口腔黏膜反应.两组Ⅱ～Ⅳ级口腔黏膜反应,差异有统计学意义(x2 =14.06,P＜0.01).除了治疗方式,Logistic回归分析发现抽烟和男性患者与严重口腔黏膜炎发生相关.结论润兴牙龈炎冲洗器和洁悠神联合使用能明显减少Ⅱ～Ⅳ级口腔黏膜反应,并能保证治疗的顺利进行.除此之外,抽烟与严重口腔黏膜炎发生相关.
목적 탐토윤흥아간염충세기화길유신용우비인암방사성구강점막염적료효,병분석기영향인소.방법 장92례비인암환자수궤분위연구조여대조조각46례,연구조채용윤흥아간염충세기화길유신장효항균재료진행구강처리,대조조행상규구강호리.결과 연구조40례완성료2개주기적화료,대조조26례완성료2개주기적화료(x2 =10.51,P=0.001).연구조3례환자인구강점막반응이연지치료,대조조공유13례환자연지료지소3d이상(x2=7.57,P=0.006).연구조40례위Ⅰ～Ⅱ급구강점막반응,6례출현Ⅲ급구강점막반응；대조조23례Ⅰ～Ⅱ급구강점막반응,23례Ⅲ～Ⅳ급구강점막반응.량조Ⅱ～Ⅳ급구강점막반응,차이유통계학의의(x2 =14.06,P＜0.01).제료치료방식,Logistic회귀분석발현추연화남성환자여엄중구강점막염발생상관.결론 윤흥아간염충세기화길유신연합사용능명현감소Ⅱ～Ⅳ급구강점막반응,병능보증치료적순리진행.제차지외,추연여엄중구강점막염발생상관.
Objective To study the efficacy of Runxin gingival flusher and Jiyoushen on nasopharyngeal carcinoma with acute oral mucositis,and analyze its influencing factors.Methods Totals of 92 nasopharyngeal carcinoma patients were randomly divided into study group(n =46) and control group(n =46).The patients of study group were treated with Runxin gingival flusher and Jiyoushen during radiation days,while control group received routine oral nursing.Results In study group,40 patients completed two cycles chemotherapy,while that of 26 patients in control group,and the difference was statistically significant (x2 =10.51,P =0.001).Patients prolonged at least 3 days in study group significantly less than that in control group for acute oral mucositis related to chemotherapy (3 vs 13,x2 =7.57,P =0.006).In study group,40 patients with Ⅰ ～ Ⅱ acute oral mucositis and 6 cases with Ⅲ acute oral mucositis were found,while 23 cases with Ⅰ ～Ⅱ acute oral mucositis and 23 cases with Ⅲ ～ Ⅳ acute oral mucositis in control group,and the difference was statistically significant (x2 =14.06,P ＜ 0.01).Logistic regression analysis found that smoking and male patients related with severe oral mucositis.Conclusions Runxin gingival flusher and Jiyoushen combined for nasopharyngeal carcinoma patients could significantly reduce the incidence of Ⅱ ～ Ⅳ acute oral mucositis,and ensure smoothing of the treatment plans.Smoking related with severe oral mucositis.