中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2009年
6期
601-603
,共3页
周怡昆%薛元明%张永红%赵仁华%苏恒%马杉%牛奔
週怡昆%薛元明%張永紅%趙仁華%囌恆%馬杉%牛奔
주이곤%설원명%장영홍%조인화%소항%마삼%우분
糖尿病%2型%振动感觉%危险因素
糖尿病%2型%振動感覺%危險因素
당뇨병%2형%진동감각%위험인소
Diabetes mellitus%type 2%Vibration perception%Risk factors
目的 研究2型糖尿病足部振动感觉损伤相关危险因素.方法 用振动感觉分析仪对3270名2型糖尿病患者行振动感觉检查,分为振动感觉减退的研究组及无振动感觉减退的对照组,测定尿蛋白、血脂、体重指数、血糖、HbA_(1C)、血清果糖胺、C肽、血压等及眼底检查.结果 研究组年龄平均为(59±12)岁,病程≥5年、24 h尿蛋白定量≥300 mg/d、有糖尿病视网膜病变、足部症状及男性比例均高于对照组,空腹血清C肽(0.56±0.45)nmol/L、餐后2 hC肽(1.81±0.95)nmol/L均低于对照组[(0.65±0.56)和(2.14±0.82)nmoL/L,P<0.05].Loistic回归分析显示,足部症状、24 h尿蛋白定量、糖尿病病程与振动感觉减退明显相关.结论 24h尿蛋白量、糖尿病病程、足部症状是2型糖尿病振动感觉损伤的危险因素.
目的 研究2型糖尿病足部振動感覺損傷相關危險因素.方法 用振動感覺分析儀對3270名2型糖尿病患者行振動感覺檢查,分為振動感覺減退的研究組及無振動感覺減退的對照組,測定尿蛋白、血脂、體重指數、血糖、HbA_(1C)、血清果糖胺、C肽、血壓等及眼底檢查.結果 研究組年齡平均為(59±12)歲,病程≥5年、24 h尿蛋白定量≥300 mg/d、有糖尿病視網膜病變、足部癥狀及男性比例均高于對照組,空腹血清C肽(0.56±0.45)nmol/L、餐後2 hC肽(1.81±0.95)nmol/L均低于對照組[(0.65±0.56)和(2.14±0.82)nmoL/L,P<0.05].Loistic迴歸分析顯示,足部癥狀、24 h尿蛋白定量、糖尿病病程與振動感覺減退明顯相關.結論 24h尿蛋白量、糖尿病病程、足部癥狀是2型糖尿病振動感覺損傷的危險因素.
목적 연구2형당뇨병족부진동감각손상상관위험인소.방법 용진동감각분석의대3270명2형당뇨병환자행진동감각검사,분위진동감각감퇴적연구조급무진동감각감퇴적대조조,측정뇨단백、혈지、체중지수、혈당、HbA_(1C)、혈청과당알、C태、혈압등급안저검사.결과 연구조년령평균위(59±12)세,병정≥5년、24 h뇨단백정량≥300 mg/d、유당뇨병시망막병변、족부증상급남성비례균고우대조조,공복혈청C태(0.56±0.45)nmol/L、찬후2 hC태(1.81±0.95)nmol/L균저우대조조[(0.65±0.56)화(2.14±0.82)nmoL/L,P<0.05].Loistic회귀분석현시,족부증상、24 h뇨단백정량、당뇨병병정여진동감각감퇴명현상관.결론 24h뇨단백량、당뇨병병정、족부증상시2형당뇨병진동감각손상적위험인소.
Objective To study the risk factors of decreased feet vibration perception in type 2 diabetic patients.Methods Three thousand two hundred and seventy patients with type 2 diabetes were divided into 2 groups according to the results of vibration perception test:group A with decreased vibration perception and group B with normal perception as control. Urinary protein content,lipid profile,body mass index,blood glucose,HbA_(1C),plasma fruetosamine,C-peptide,and blood pressure were measured,and ocular fundus were examined.Results The subiects in group A were older than those in group B[(59±12)vs(56±12)years,P<0.05].The percentage of longer diabetes duration(≥5 years),24 h urinary protein content≥300 mg/d,combined diabetic retinopathy,foot symptorms and male sex were higher in group A than those in group B.Fasting and postprandial C-peptide levels[(0.56±0.45 and 1.81±0.95)nmol/L]in group A were lower than those in group B[(0.65±0.56and 2.14±0.82)nmol/L,P<0.05].Logistic regression analysis showed that the independent risk factors of decreared feet vibration perception in type 2 diabetic patients were 24 h urinary protein,foot symptoms and duration of diabetes.Conclusion 24 h urinary protein content,duration of diabetes,and foot symptoms seem to be the most important risk factors related to decreased vibration perception in type 2 diabetes.
