中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
17期
93-94,95
,共3页
肠易激综合征%匹维溴胺%度洛西汀%疗效
腸易激綜閤徵%匹維溴胺%度洛西汀%療效
장역격종합정%필유추알%도락서정%료효
irritable bowel syndrome%pinaverium bromide%dutoxetine%effect comparative research
目的：观察匹维溴胺联用小剂量抗抑郁剂度洛西汀对肠易激综合征的临床疗效。方法将138例肠易激综合征患者采用随机双盲法均分为试验组和对照组，试验组给予匹维溴胺联合度洛西汀治疗，对照组给予匹维溴胺治疗，均连续用药8周。分别于治疗1，2，4，8周末对患者进行临床疗效评价，并记录患者症状改善情况及不良反应发生情况。结果治疗第1周末，2组间临床疗效比较差异无统计学意义（ P＞0.05）。第2，4，8周末两组临床疗效比较，差异有统计学意义（ P<0.05）；尤其在第8周末差异更为明显，试验组临床总有效率为91.30%，对照组为73.91%。治疗后两组患者抑郁状态均有所改善，但是试验组患者改善更明显（ P<0.05）。两组患者均有不良反应发生，但发生率差异无统计学意义（ P＞0.05）。结论匹维溴胺联用小剂量度洛西汀治疗肠易激综合征，可有效缓解胃肠道症状，且起效快、作用持久，疗效优于单纯口服匹维溴胺，值得临床推广与使用。
目的：觀察匹維溴胺聯用小劑量抗抑鬱劑度洛西汀對腸易激綜閤徵的臨床療效。方法將138例腸易激綜閤徵患者採用隨機雙盲法均分為試驗組和對照組，試驗組給予匹維溴胺聯閤度洛西汀治療，對照組給予匹維溴胺治療，均連續用藥8週。分彆于治療1，2，4，8週末對患者進行臨床療效評價，併記錄患者癥狀改善情況及不良反應髮生情況。結果治療第1週末，2組間臨床療效比較差異無統計學意義（ P＞0.05）。第2，4，8週末兩組臨床療效比較，差異有統計學意義（ P<0.05）；尤其在第8週末差異更為明顯，試驗組臨床總有效率為91.30%，對照組為73.91%。治療後兩組患者抑鬱狀態均有所改善，但是試驗組患者改善更明顯（ P<0.05）。兩組患者均有不良反應髮生，但髮生率差異無統計學意義（ P＞0.05）。結論匹維溴胺聯用小劑量度洛西汀治療腸易激綜閤徵，可有效緩解胃腸道癥狀，且起效快、作用持久，療效優于單純口服匹維溴胺，值得臨床推廣與使用。
목적：관찰필유추알련용소제량항억욱제도락서정대장역격종합정적림상료효。방법장138례장역격종합정환자채용수궤쌍맹법균분위시험조화대조조，시험조급여필유추알연합도락서정치료，대조조급여필유추알치료，균련속용약8주。분별우치료1，2，4，8주말대환자진행림상료효평개，병기록환자증상개선정황급불량반응발생정황。결과치료제1주말，2조간림상료효비교차이무통계학의의（ P＞0.05）。제2，4，8주말량조림상료효비교，차이유통계학의의（ P<0.05）；우기재제8주말차이경위명현，시험조림상총유효솔위91.30%，대조조위73.91%。치료후량조환자억욱상태균유소개선，단시시험조환자개선경명현（ P<0.05）。량조환자균유불량반응발생，단발생솔차이무통계학의의（ P＞0.05）。결론필유추알련용소제량도락서정치료장역격종합정，가유효완해위장도증상，차기효쾌、작용지구，료효우우단순구복필유추알，치득림상추엄여사용。
Objective To investigate the clinical effects of pinaverium bromide combined with low-dose dutoxetine in treating irritable bowel syndrome ( IBS ) in order to provide the important reference for clinic. Methods 138 patients with IBS were randomly divided into 2 groups. The experimental group was treated with pinaverium bromide combined with dutoxetine, while the control group was treated with simple pinaverium bromide for consecutive 8 weeks. The clinical efficacy was evaluated at the ends of 1, 2, 4, 8 weeks of treatment respectively. The symptoms improvement situation and the occurrence of adverse reactions were recorded. Resuts The clinical efficacy after 1-week treatment had no statistical difference between the two groups ( P>0. 05 ) , while which at the ends of 2, 4, 8 weeks the difference between the two groups ( P<0. 05 );especially the difference at the end of 8 weeks was more significant. The clinical total ef-fective rate was 91. 3% in the experimental group and 73. 9% in the control group. The depression symptom after treatment in the two groups were improved to some extent, but the improvement in the experimental group was more significant, the difference had statistical significance ( P<0. 05 ) . The adverse reactions occurred in the two groups without statistical difference ( P>0. 05 ) . Conclusion Pinaveri-um bromide combined with low-dose dutoxetine in treating IBS can effectively relieve the gastrointestinal symptoms, has rapid effect onset, lasting effect and better therapeutic effect than simple pinaverium bromide, which is worthy of being promoted and applied in clinic.
