CAJ | 학술논문

目的：探讨乌司他丁对心肺复苏后心肌功能障碍的保护作用。方法将成人心肺复苏自主循环恢复后的患者33例随机分为对照组（16例）按常规治疗，治疗组（17例）在常规心肺复苏综合治疗基础上加用乌司他丁20万单位静脉推注，每12 h推注1次，5 d为1个疗程。记录治疗前及治疗后12、24、72 h患者的血乳酸、心肌肌钙蛋白（ cTnI）及B型利钠肽（ BNP）水平并计算12、24、72 h患者的血乳酸清除率。结果乌司他丁治疗组患者cTnI，治疗后72h较对照组差异有统计学意义（ P＜0．05），BNP高峰（24 h）明显下降（P＜0．05）。24、72 h乳酸清除率升高（P＜0．05），组织灌注改善，住院天数缩短，病死率下降（P＜0．05）。结论乌司他丁能改善心肺复苏术后患者的组织灌注、对心肌功能障碍有一定保护作用，对该类患者预后有积极影响。
목적：탐토오사타정대심폐복소후심기공능장애적보호작용。방법장성인심폐복소자주순배회복후적환자33례수궤분위대조조（16례）안상규치료，치료조（17례）재상규심폐복소종합치료기출상가용오사타정20만단위정맥추주，매12 h추주1차，5 d위1개료정。기록치료전급치료후12、24、72 h환자적혈유산、심기기개단백（ cTnI）급B형리납태（ BNP）수평병계산12、24、72 h환자적혈유산청제솔。결과오사타정치료조환자cTnI，치료후72h교대조조차이유통계학의의（ P＜0．05），BNP고봉（24 h）명현하강（P＜0．05）。24、72 h유산청제솔승고（P＜0．05），조직관주개선，주원천수축단，병사솔하강（P＜0．05）。결론오사타정능개선심폐복소술후환자적조직관주、대심기공능장애유일정보호작용，대해류환자예후유적겁영향。
Objective to investigate the protective effects of ulinastatin on myocardialdysfunction after cardiopulmonary resuscitation . Methods The adult cardiopulmonary resuscitation ( CPR) of spontaneous circulation recovery after 33 patients were randomly divided into control group(16 cases) by conventional treatment,the treatment group(17 cases) based on conventional cardiopulmonary resusci-tation(CPR) comprehensive treatment combined with ulinastatin 200000 units of intravenous injection,once every 12 h push note 1,5 d for a course of treatment.Recorded before and after treatment for 12,24,72 h of the patient's blood lactic acid,myocardial troponin(cT-nI) and b-type natriuretic peptide(BNP) levels and calculate the 12,24,72 h of the patient's blood lactate clearance rate.Results Ulinastatin treatment group patients cTnI ,72 h after treatment than the control group was statistically significant difference ( P<0 .05 ) , the peak of the BNP(24 h) significantly decreased(P<0.05).24,72 h increased lactate clearance rate(P<0.05),improve tissue perfusion,shorten hospitalization days,the case fatality rate decreased(P<0.05).Conclusion Ulinastatin can improve cardiopulmo-nary resuscitation tissue perfusion in patients with myocardial dysfunction ,have certain protection effect ,positive impact on theprognosis of the patients with .