安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2014年
12期
2320-2321,2322
,共3页
宫颈癌筛查%HCⅡ检测法%HCⅡ+LBC联合检测法%宫颈癌
宮頸癌篩查%HCⅡ檢測法%HCⅡ+LBC聯閤檢測法%宮頸癌
궁경암사사%HCⅡ검측법%HCⅡ+LBC연합검측법%궁경암
cervical cancer screening%HCⅡassay%HCⅡassay combined with LBC%cervical cancer
目的：探讨HPV DNA第二代杂交捕获（ HCⅡ）检测法和液基细胞学（ LBC ）检测法及其联合应用在宫颈癌筛查诊断的价值。方法选取该院2013年3-10月门诊及体检中心就诊的患者500例，分别行LBC检测、HCⅡ法检测，对任一方法结果阳性者行阴道镜病理活检。结果500例LBC异常占10．6％；HCⅡ异常占6．4％；HCⅡ＋LBC异常占11．2％。106例检测阳性患者按要求做阴道镜病理活检，宫颈炎症、CIN Ⅰ、CIN Ⅱ、CIN Ⅲ、宫颈癌发病率分别为74．5％、15．1％、6．6％、2．8％、0．9％；HCⅡ＋LBC 联合检测法阳性率分别为17．7％、56．2％、85．7％、100％、100％；单独的HCⅡ检测法阳性率分别为45．6％、62．5％、71．4％、100％、100％，随着病理恶性等级增高阳性率增高。结论 HCⅡ＋LBC联合检测法与单独的HCⅡ检测法都是宫颈癌筛查的好方法。 HCⅡ＋LBC联合检测法是宫颈癌筛查的首选。但对于经济不发达的城乡地区的宫颈癌筛查也可采用单独的HCⅡ检测法，以便及早发现宫颈癌及时诊治。
目的：探討HPV DNA第二代雜交捕穫（ HCⅡ）檢測法和液基細胞學（ LBC ）檢測法及其聯閤應用在宮頸癌篩查診斷的價值。方法選取該院2013年3-10月門診及體檢中心就診的患者500例，分彆行LBC檢測、HCⅡ法檢測，對任一方法結果暘性者行陰道鏡病理活檢。結果500例LBC異常佔10．6％；HCⅡ異常佔6．4％；HCⅡ＋LBC異常佔11．2％。106例檢測暘性患者按要求做陰道鏡病理活檢，宮頸炎癥、CIN Ⅰ、CIN Ⅱ、CIN Ⅲ、宮頸癌髮病率分彆為74．5％、15．1％、6．6％、2．8％、0．9％；HCⅡ＋LBC 聯閤檢測法暘性率分彆為17．7％、56．2％、85．7％、100％、100％；單獨的HCⅡ檢測法暘性率分彆為45．6％、62．5％、71．4％、100％、100％，隨著病理噁性等級增高暘性率增高。結論 HCⅡ＋LBC聯閤檢測法與單獨的HCⅡ檢測法都是宮頸癌篩查的好方法。 HCⅡ＋LBC聯閤檢測法是宮頸癌篩查的首選。但對于經濟不髮達的城鄉地區的宮頸癌篩查也可採用單獨的HCⅡ檢測法，以便及早髮現宮頸癌及時診治。
목적：탐토HPV DNA제이대잡교포획（ HCⅡ）검측법화액기세포학（ LBC ）검측법급기연합응용재궁경암사사진단적개치。방법선취해원2013년3-10월문진급체검중심취진적환자500례，분별행LBC검측、HCⅡ법검측，대임일방법결과양성자행음도경병리활검。결과500례LBC이상점10．6％；HCⅡ이상점6．4％；HCⅡ＋LBC이상점11．2％。106례검측양성환자안요구주음도경병리활검，궁경염증、CIN Ⅰ、CIN Ⅱ、CIN Ⅲ、궁경암발병솔분별위74．5％、15．1％、6．6％、2．8％、0．9％；HCⅡ＋LBC 연합검측법양성솔분별위17．7％、56．2％、85．7％、100％、100％；단독적HCⅡ검측법양성솔분별위45．6％、62．5％、71．4％、100％、100％，수착병리악성등급증고양성솔증고。결론 HCⅡ＋LBC연합검측법여단독적HCⅡ검측법도시궁경암사사적호방법。 HCⅡ＋LBC연합검측법시궁경암사사적수선。단대우경제불발체적성향지구적궁경암사사야가채용단독적HCⅡ검측법，이편급조발현궁경암급시진치。
Objective To investigate the value in the diagnosis of cervical cancer screening by using the method of second -generation hybrid capture HPV DNA(HCⅡ) only and combined with liquid -based cytology(LBC).Methods five hundred cases of patients were selected from March to October 2013 in Suzhou Municipal Hospital ,which underwent LBC detection and HCⅡassay respectively . Any patient with positive result for either method would have colposcopy biopsy .Results Among the 500 cases of patients ,LBC,HCⅡand HCⅡ +LBC abnormalities accounted for 10.6%,6.4%,11.2%respectively.A hundred and six patients had colposcopy biopsy . The incidence rates of inflammation of the cervix ,CINⅠ,CINⅡ,CINⅢ,cervical cancer were 74.5%,15.1%,6.6%,2.8%,0.9%respectively.HCⅡ +LBC positive rates of detection were 17.7%,56.2%,85.7%,100%,100% respectively.HCⅡ single positive rates were 45.6%,62.5%,71.4%,100%and 100%respectively,which increased with the malignant grade of pathology .Conclusions HCⅡ +LBC and HCⅡassays are good ways in cervical cancer screening .HCⅡ +LBC is the preferred method of cervical cancer screening .But for the economically underdeveloped rural and urban areas ,single HCⅡassay can also be use for early detection ,diagno-sis and treatment of cervical cancer .
