安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2014年
12期
2315-2316,2317
,共3页
D-二聚体%纤维蛋白原%胱抑素C%糖尿病肾病
D-二聚體%纖維蛋白原%胱抑素C%糖尿病腎病
D-이취체%섬유단백원%광억소C%당뇨병신병
D-dimer%fibrinogen%Cystatin C%diabetic nephropathy
目的：探讨D-二聚体（ DD）、纤维蛋白原（ Fib）及胱抑素C（ CysC）水平与2型糖尿病肾病的关系。方法选择2012年1月-2013年12月在该院内分泌科住院的2型糖尿病患者185例，健康体检者47例为对照组（ NC组）。测定其空腹DD、Fib、CysC水平，并按照24 h尿白蛋白排泄率（ UAER）将糖尿病患者分为：正常蛋白尿组（ NA组，UAER＜30 mg· d-1）108例、微量蛋白尿组（MA组，UAER 30～300 mg· d-1）51例、临床蛋白尿组（CP组，UAER ＞300 mg· d-1）26例。观察DD、Fib、CysC与糖尿病肾病之间的关系。结果 MA组和CP组DD、FIB、CysC水平均显著高于NC组及NA组，差异具有统计学意义（均P＜0．05），CP组与MA组相比亦明显升高（均P＜0．05）；MA组和CP组DD、CysC阳性率显著高于NA组（均P＜0．05）。直线相关分析显示DD、FIB和CysC与UAER均呈正相关（r分别为0．380，0．480，0．819，P均＜0．05）结论2型糖尿病患者处于血栓前状态和继发性纤溶亢进，糖尿病肾病患者尤为明显；DD、FIB和CysC水平与糖尿病肾病的发生、发展密切相关。
目的：探討D-二聚體（ DD）、纖維蛋白原（ Fib）及胱抑素C（ CysC）水平與2型糖尿病腎病的關繫。方法選擇2012年1月-2013年12月在該院內分泌科住院的2型糖尿病患者185例，健康體檢者47例為對照組（ NC組）。測定其空腹DD、Fib、CysC水平，併按照24 h尿白蛋白排洩率（ UAER）將糖尿病患者分為：正常蛋白尿組（ NA組，UAER＜30 mg· d-1）108例、微量蛋白尿組（MA組，UAER 30～300 mg· d-1）51例、臨床蛋白尿組（CP組，UAER ＞300 mg· d-1）26例。觀察DD、Fib、CysC與糖尿病腎病之間的關繫。結果 MA組和CP組DD、FIB、CysC水平均顯著高于NC組及NA組，差異具有統計學意義（均P＜0．05），CP組與MA組相比亦明顯升高（均P＜0．05）；MA組和CP組DD、CysC暘性率顯著高于NA組（均P＜0．05）。直線相關分析顯示DD、FIB和CysC與UAER均呈正相關（r分彆為0．380，0．480，0．819，P均＜0．05）結論2型糖尿病患者處于血栓前狀態和繼髮性纖溶亢進，糖尿病腎病患者尤為明顯；DD、FIB和CysC水平與糖尿病腎病的髮生、髮展密切相關。
목적：탐토D-이취체（ DD）、섬유단백원（ Fib）급광억소C（ CysC）수평여2형당뇨병신병적관계。방법선택2012년1월-2013년12월재해원내분비과주원적2형당뇨병환자185례，건강체검자47례위대조조（ NC조）。측정기공복DD、Fib、CysC수평，병안조24 h뇨백단백배설솔（ UAER）장당뇨병환자분위：정상단백뇨조（ NA조，UAER＜30 mg· d-1）108례、미량단백뇨조（MA조，UAER 30～300 mg· d-1）51례、림상단백뇨조（CP조，UAER ＞300 mg· d-1）26례。관찰DD、Fib、CysC여당뇨병신병지간적관계。결과 MA조화CP조DD、FIB、CysC수평균현저고우NC조급NA조，차이구유통계학의의（균P＜0．05），CP조여MA조상비역명현승고（균P＜0．05）；MA조화CP조DD、CysC양성솔현저고우NA조（균P＜0．05）。직선상관분석현시DD、FIB화CysC여UAER균정정상관（r분별위0．380，0．480，0．819，P균＜0．05）결론2형당뇨병환자처우혈전전상태화계발성섬용항진，당뇨병신병환자우위명현；DD、FIB화CysC수평여당뇨병신병적발생、발전밀절상관。
Objective To evaluate the association between DD ,Fib,CysC and diabetic nephropathy in type 2 diabetic patients .Meth-ods One hundred and eighty-five patients with type 2 diabetes mellitus treated in Endocrinology Department of North Hospital of Huainan Xinhua Medical Group during June 2012 to April 2013 were selected ,and 47 healthy people were used for control group .These patients were classified into three groups according to the urine albumin excretion rate (UAER)including normal albuminuria group (NA group:UAER<30 mg · d-1 ) , micro albuminuria group ( MA group:UAER 30 ~300 mg · d-1 ) and clinical protein uria group ( CP group:UAER >300 m· d-1 ) .Results Nephropathy was found in 78 subjects with albuminuria in 52 and proteinuria in 26 subjects . The levels of DD,FIB and CysC in group MA and group CP were significantly higher than those in the group NC or NA (P<0.05);and those in group CP were significantly higher than in group MA (P<0.05).Correlation analysis suggested that DD ,FIB and CysC were all positively correlated with UAER(r were 0.380,0.480,0.819 respectively,P <0.05).Conclusions The patients with type 2 dia-betes mellitus are in prethrombotic state and secondary hyperfibrinolysis ,especially those with diabetic nephropathy .FIB,DD and CysC are related to the incidence and the development of diabetic nephropathy .
