CAJ | 학술논문

目的：观察慢性心力衰竭患者心脏再同步化治疗（ CRT）治疗前后心功能及血浆非对称性二甲基精氨酸（ ADMA）和血浆N-端脑钠肽前体（ NT-proBNP）水平的变化。方法21例慢性心力衰竭患者行CRT治疗，测定治疗前及治疗后3个月、6个月NYHA心功能分级、左室射血分数（ LVEF）、左室舒张末内径（ LVEDD）及血浆ADMA、NT-proBNP变化。结果21例慢性心力衰竭患者心衰症状改善，NYHA心功能分级提高，LVEF、LVEDD、NT-proBNP等心功能指标改善，血浆NT-proBNP和ADMA水平与治疗前比较明显下降，差异有统计学意义（P＜0．05）。结论慢性心衰经CRT治疗后心功能改善，血浆NT-proBNP及ADMA水平降低。
목적：관찰만성심력쇠갈환자심장재동보화치료（ CRT）치료전후심공능급혈장비대칭성이갑기정안산（ ADMA）화혈장N-단뇌납태전체（ NT-proBNP）수평적변화。방법21례만성심력쇠갈환자행CRT치료，측정치료전급치료후3개월、6개월NYHA심공능분급、좌실사혈분수（ LVEF）、좌실서장말내경（ LVEDD）급혈장ADMA、NT-proBNP변화。결과21례만성심력쇠갈환자심쇠증상개선，NYHA심공능분급제고，LVEF、LVEDD、NT-proBNP등심공능지표개선，혈장NT-proBNP화ADMA수평여치료전비교명현하강，차이유통계학의의（P＜0．05）。결론만성심쇠경CRT치료후심공능개선，혈장NT-proBNP급ADMA수평강저。
Objective To investigate changes in heart function and the levels of asymmetric dimethylarginine ( ADMA) and N-terminal pro-brain natriuretic peptide(NT-proBNP) before and after cardiac resynchronization therapy (CRT) treatment in patients with chron-ic heart failure .Methods The levels of ADMA and NT-proBNP were measured in 21 heart failure patients before and three and six months after receiving CRT .The NYHA functional class ,left ventricular ejection fraction ,left ventricular end-diastolic dimension were also measured by echocardiography at the same time .Results Compared with pro-CRT,the NYHA functional class ,left ventricular e-jection fraction and the synchrony index improved ,while left ventricular end-diastolic dimension decreased after treatment of CRT .The plasma concentration of ADMA and NT-proBNP significantly decreased too . There was significant difference about them before and af-ter CRT treatment(P<0.05).Conclusions Cardiac function can be improved and the plasma levels of ADMA and NT-proBNP are decreased by treatment of CRT .