CAJ | 학술논문

目的：探讨研究2型糖尿病肾病患者肾功能、糖化血红蛋白、尿微量白蛋白与血脂代谢的关系。方法120例诊断患者依尿微量白蛋白排泄率分为正常白蛋白尿（ NAU）组、微量白蛋白尿（ MAU）组和临床蛋白尿（ CAU）组，依糖化血红蛋白水平分为A、B、C三组，另外选30例体检健康者作为对照组（ NC）。检测各种生化指标：空腹血糖（ FBG）、胆固醇（ TCH）、甘油三酯（TG）、血清素氮（BUN）、血清肌酐（Cr）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、糖化血红蛋白（HbA1C）、尿微量白蛋白（mAlb）。结果 T2DM组和NC组相比，FBG、TG、TC、LDL-C、HbA1C水平高于NC组（P＜0．01），HDL-C低于对照组（P＜0．05）；CAU组、MAU组的FBG、TG、TC、LDL-C、HbA1C指标要明显的高于NAU组（P＜0．05）；CAU的FBG、TG、TC、LDL-C、HbA1C明显大于MAU组（P＜0．01），CAU 组的HDL要低于MAU 组和NUA组（P＜0．05），2型糖尿病肾病患者在FPG、HbA1C、TCH、TG、UAE和NC组相比较差异有统计学意义（P＜0．05），BUN、Cr与NC组相对比，其差异无统计学意义（P＞0．05）。 T2DM患者各组之间FPG、HbA1C相互比较，差异有统计学意义（P＜0．05）；而各组间的TCH、TG、BUN、Cr相互比较无统计学意义（ P＞0．05）。结论2型糖尿病肾病患者的尿微量白蛋白增高程度与糖化血红蛋白的增高有关，而尿微量白蛋白是糖尿病早期肾脏损害的灵敏指标，联合检测 HbA1 C、mAlb以及各项血脂水平对糖尿病肾病的早期预防诊断及治疗有重要意义。
목적：탐토연구2형당뇨병신병환자신공능、당화혈홍단백、뇨미량백단백여혈지대사적관계。방법120례진단환자의뇨미량백단백배설솔분위정상백단백뇨（ NAU）조、미량백단백뇨（ MAU）조화림상단백뇨（ CAU）조，의당화혈홍단백수평분위A、B、C삼조，령외선30례체검건강자작위대조조（ NC）。검측각충생화지표：공복혈당（ FBG）、담고순（ TCH）、감유삼지（TG）、혈청소담（BUN）、혈청기항（Cr）、고밀도지단백（HDL-C）、저밀도지단백（LDL-C）、당화혈홍단백（HbA1C）、뇨미량백단백（mAlb）。결과 T2DM조화NC조상비，FBG、TG、TC、LDL-C、HbA1C수평고우NC조（P＜0．01），HDL-C저우대조조（P＜0．05）；CAU조、MAU조적FBG、TG、TC、LDL-C、HbA1C지표요명현적고우NAU조（P＜0．05）；CAU적FBG、TG、TC、LDL-C、HbA1C명현대우MAU조（P＜0．01），CAU 조적HDL요저우MAU 조화NUA조（P＜0．05），2형당뇨병신병환자재FPG、HbA1C、TCH、TG、UAE화NC조상비교차이유통계학의의（P＜0．05），BUN、Cr여NC조상대비，기차이무통계학의의（P＞0．05）。 T2DM환자각조지간FPG、HbA1C상호비교，차이유통계학의의（P＜0．05）；이각조간적TCH、TG、BUN、Cr상호비교무통계학의의（ P＞0．05）。결론2형당뇨병신병환자적뇨미량백단백증고정도여당화혈홍단백적증고유관，이뇨미량백단백시당뇨병조기신장손해적령민지표，연합검측 HbA1 C、mAlb이급각항혈지수평대당뇨병신병적조기예방진단급치료유중요의의。
Objective To investigate the relationship among glycosylated hemoglobin (GHbA1C),the disturbance of lipids metabolism and urinous albumin ( mAlb) excretion rate in type 2 diabetic nephropathy ( DN) .Methods A hundred and twenty patients ,in accord-ance with the urine trace albumin excretion rate ,were assigned into normal albuminuria (NAU) group,microalbuminuria(MAU) group and clinical proteinuria ( CAU) group,and in accordance with the glycated hemoglobin level were assigned into group A ,B,and C, meanwhile,30 healthy people were chosen as the control group (NC).Various biochemical indexes including FBG ,HbA1C,TCH,TG, BUN,Cr,HDL-C,LDL-C,mAlb were detected.Results Compared with NC group,the detection rates of FBG,TG,TC,LDL-C,HbA1C was higher in T2DM group(P<0.01),while HDL-C was lower(P<0.05).FBG,TG,TC,LDL-C,HbA1C indexes in CAU,MAU group were significantly higher than those in NUA group (P<0.05).FBG,TG,LDL-C,HbA1C in CAU group were significantly higher than those in MAU group(P<0.01).HDL in CAU group was lower than that in MAU group and NUA group (P<0.05).FPG,HbA1C, TCH,TG and UAE of patients with type 2 diabetic nephropathy were significantly different from those in NC group (P<0.05),while BUN,Cr,compared with NC group,had no statistically significant difference (P>0.05).FPG,HbA1C of T2DM patients were statisti-cally different among different groups(P<0.05),while TCH,TG,BUN,Cr had no statistical significance(P>0.05).Conclusions Increased urine trace albumin levels of type 2 diabetic nephropathic patients are associated with increased glycosylated hemoglobin .U-rine trace albumin is a sensitive index of early diabetic kidney damage .Joint detection of HbA l C,mAlb and lipid levels will have impor-tant significance in diabetic nephropathy ’ s early prevention ,diagnosis and treatment .