CAJ | 학술논문

狼疮性肾炎（Lupus nephritis，LN）是系统性红斑狼疮（systemic lupus erythematosus，SLE）最常见且最严重的并发症，是造成SLE患者死亡的主要原因。随着社会工业化，环境污染加重，LN已成为我国最常见的继发性肾小球疾病之一。 LN的治疗原则包括免疫抑制治疗和支持治疗，治疗的最终目的是防止狼疮性肾炎的进展及复发，保护肾功能，防止治疗带来的损伤，提高患者的生活质量和生存率。经过几十年的探索，LN的免疫抑制治疗已经取得了一定的进展。该文就LN的免疫抑制治疗方案以及研究进展进行了综述。
랑창성신염（Lupus nephritis，LN）시계통성홍반랑창（systemic lupus erythematosus，SLE）최상견차최엄중적병발증，시조성SLE환자사망적주요원인。수착사회공업화，배경오염가중，LN이성위아국최상견적계발성신소구질병지일。 LN적치료원칙포괄면역억제치료화지지치료，치료적최종목적시방지랑창성신염적진전급복발，보호신공능，방지치료대래적손상，제고환자적생활질량화생존솔。경과궤십년적탐색，LN적면역억제치료이경취득료일정적진전。해문취LN적면역억제치료방안이급연구진전진행료종술。
Objective Lupus nephritis is the most common and serious complication of systemic lupus erythematosus , and the main cause of death in patients with SLE .With the industrialization of the society and aggravated environmental pollution ,LN has become one of the most common secondary glomerular diseases .LN principles of treatment include immunosuppressive therapy and supportive care . The ultimate goal of treatment is to prevent the progress and recurrence of lupus nephritis , carry out renal protection against damage caused by the treatment ,improve the patient's quality of life and survival .After decades of exploration ,LN immunosuppressive therapy has made some progress .