CAJ | 학술논문

目的探讨芪丹化瘀方对气虚血瘀证急性期缺血性卒中的临床疗效和机制.方法将60例气虚血瘀证急性期缺血性卒中患者,按随机数字表法分为芪丹化瘀组30例,脑心通组30例.在常规治疗基础上,芪丹化瘀组患者应用芪丹化瘀方,脑心通组加用步长脑心通胶囊,均治疗21d,观察2组中医气虚血瘀证证候积分以及神经缺损评分的变化,检测2组脑血流动力学指标,同时进行安全性分析.结果 2组治疗后,芪丹化瘀组总有效率、神经功能缺损评分、中医证候积分改善程度,均优于脑心通组治疗后,差异有统计学意义[86.7％(26/30)比73.3％ (22/30);(7±3)分比(10±5)分;气虚证:(7.0±2.5)分比(9.1±3.2)分;血瘀证:(8.0±3.1)分比(9.5±3.1)分,P＜0.05或P＜0.01];治疗后脑血流速度较治疗前均有明显改善,与脑心通组治疗后比较,差异有统计学意义(P＜0.05或P＜0.01).结论芪丹化瘀方对缺血性卒中急性期气虚血瘀证具有较好的治疗效果.
목적 탐토기단화어방대기허혈어증급성기결혈성졸중적림상료효화궤제.방법 장60례기허혈어증급성기결혈성졸중환자,안수궤수자표법분위기단화어조30례,뇌심통조30례.재상규치료기출상,기단화어조환자응용기단화어방,뇌심통조가용보장뇌심통효낭,균치료21d,관찰2조중의기허혈어증증후적분이급신경결손평분적변화,검측2조뇌혈류동역학지표,동시진행안전성분석.결과 2조치료후,기단화어조총유효솔、신경공능결손평분、중의증후적분개선정도,균우우뇌심통조치료후,차이유통계학의의[86.7％(26/30)비73.3％ (22/30);(7±3)분비(10±5)분;기허증:(7.0±2.5)분비(9.1±3.2)분;혈어증:(8.0±3.1)분비(9.5±3.1)분,P＜0.05혹P＜0.01];치료후뇌혈류속도교치료전균유명현개선,여뇌심통조치료후비교,차이유통계학의의(P＜0.05혹P＜0.01).결론 기단화어방대결혈성졸중급성기기허혈어증구유교호적치료효과.
Objective To study the clinical effect of Qidan Huayu Fang on acute ischemic stroke.Methods Totally 60 cases of patients with acute ischemic stroke (qi deficiency and blood stasis syndrome) were randomly (random number table) divided into Qidan Huayu Group (n =30) and Naoxintong Group (n =30).In addition to regular treatment,Qidan Huayu Group was given Qidan Huayu Fang,and Naoxintong Group was given Naoxintong Capsule.All the patients were treated for 21d.TCM syndrome scores and nerve defects scores were observed.Cerebral hemodynamic indexes of the two groups were compared.Safety analysis was also perforoed.Results After treatment,Qidan Huayu Group was better than Naoxintong Group in total effective rate,neural function defect scores and improvement of TCM syndrome scores,and the difference were statistically significant [86.7％ (26/ 30) vs.73.3％ (22/30),(7 ±.3) points vs.(10 ±5) points; Qi deficiency syndrome:(7.0 ±2.5) points vs.(9.1 ±3.2) points; bloodstasis:(8.0±3.1) points vs.(9.5 ±3.1) points,P＜0.05 or P＜0.01].After treatment,cerebral bloodflow velocity was obviously improved than before treatment.Compared with Naoxintong Group,the difference was statistically significant (P ＜ 0.05 or P ＜ 0.01).Conclusion Qidan Huayu Fang has relatively good therapeutic effects on acute ischemic stroke (qi deficiency and blood stasis syndrome).