中国老年学杂志
中國老年學雜誌
중국노년학잡지
CHINESE JOURNAL OF GERONTOLOGY
2014年
19期
5351-5353
,共3页
郭振涛%郭民%赵学兰%潘广华
郭振濤%郭民%趙學蘭%潘廣華
곽진도%곽민%조학란%반엄화
慢性肾脏病%血管紧张素受体阻滞剂%钙离子通道阻滞剂%蛋白尿
慢性腎髒病%血管緊張素受體阻滯劑%鈣離子通道阻滯劑%蛋白尿
만성신장병%혈관긴장소수체조체제%개리자통도조체제%단백뇨
Chronic kidney disease%Angiotensin receptor blockers%Calcium channel blockers%Proteinuria
目的:比较血管紧张素Ⅱ受体阻滞剂缬沙坦和钙离子通道阻滞剂西尼地平对慢性肾脏病早期合并高血压患者的肾脏和心血管的保护作用。方法选取40例慢性肾脏病早期并且合并高血压的患者随机分配接受缬沙坦(20例)和西尼地平(20例)治疗12个月。分别测量治疗前后患者的血压、血清肌酐、肌酐清除率,蛋白尿、颈动脉内膜中层厚度( IMT)、血浆白细胞介素-6、血脂水平。在治疗前,确保分配到两组的病人上述测量指标没有显著差异。结果经过12个月的观察期后,两组患者在血压控制方面无明显差异,然而在血清肌酐、蛋白尿、颈动脉内膜中层厚度、血浆白细胞介素-6、血脂水平方面,氯沙坦组较西尼地平组明显降低上述指标。结论氯沙坦在慢性肾脏病早期合并高血压患者的肾脏和心血管保护方面优于西尼地平。
目的:比較血管緊張素Ⅱ受體阻滯劑纈沙坦和鈣離子通道阻滯劑西尼地平對慢性腎髒病早期閤併高血壓患者的腎髒和心血管的保護作用。方法選取40例慢性腎髒病早期併且閤併高血壓的患者隨機分配接受纈沙坦(20例)和西尼地平(20例)治療12箇月。分彆測量治療前後患者的血壓、血清肌酐、肌酐清除率,蛋白尿、頸動脈內膜中層厚度( IMT)、血漿白細胞介素-6、血脂水平。在治療前,確保分配到兩組的病人上述測量指標沒有顯著差異。結果經過12箇月的觀察期後,兩組患者在血壓控製方麵無明顯差異,然而在血清肌酐、蛋白尿、頸動脈內膜中層厚度、血漿白細胞介素-6、血脂水平方麵,氯沙坦組較西尼地平組明顯降低上述指標。結論氯沙坦在慢性腎髒病早期閤併高血壓患者的腎髒和心血管保護方麵優于西尼地平。
목적:비교혈관긴장소Ⅱ수체조체제힐사탄화개리자통도조체제서니지평대만성신장병조기합병고혈압환자적신장화심혈관적보호작용。방법선취40례만성신장병조기병차합병고혈압적환자수궤분배접수힐사탄(20례)화서니지평(20례)치료12개월。분별측량치료전후환자적혈압、혈청기항、기항청제솔,단백뇨、경동맥내막중층후도( IMT)、혈장백세포개소-6、혈지수평。재치료전,학보분배도량조적병인상술측량지표몰유현저차이。결과경과12개월적관찰기후,량조환자재혈압공제방면무명현차이,연이재혈청기항、단백뇨、경동맥내막중층후도、혈장백세포개소-6、혈지수평방면,록사탄조교서니지평조명현강저상술지표。결론록사탄재만성신장병조기합병고혈압환자적신장화심혈관보호방면우우서니지평。
Objective Objective To compare the protective effects of angiotensin II receptor blocker losartan and calcium channel blockercilnidipine on early stage of chronic kidney disease in patients with renal and cardiovascular .Methods 40 patients with early stage of chronic kidney disease and hypertension patients were randomly assigned to receive losartan (20 cases) and cilnidipine (20 cases) for 12 months.Blood pressure, the levels of serum creatinine, creatinine clearance, urinary protein, carotid artery intima-media thickness (IMT), interleukin(IL)-6, serum lipid of the two groups were measured before and after treatment .Results Before treatment, there were no signif-icant differences of the measurement indexes between the two groups .After 12 months, there was no significant difference of blood pressure between the two groups;however, the levels of serum creatinine , proteinuria, carotid intima-media thickness, IL-6, lipid levels in losartan group were significantly reduced than those of cilnidipine group .Conclusions The effects of losartan in the early stage of chronic kidney disease in patients with renal and cardiovascular protection is better than that of cilnidipine .