中国麻风皮肤病杂志
中國痳風皮膚病雜誌
중국마풍피부병잡지
CHINA JOURNAL OF LEPROSY AND SKIN DISEASES
2014年
5期
286-288
,共3页
尖锐湿疣%人乳头瘤病毒%HBD-2%HBD-3%LL-37
尖銳濕疣%人乳頭瘤病毒%HBD-2%HBD-3%LL-37
첨예습우%인유두류병독%HBD-2%HBD-3%LL-37
condyloma acuminatum%human papilloma virus%human beta defensin-2%human beta defen-sin-3%antimicrobial peptide LL-37
目的：检测尖锐湿疣患者皮损中抗菌肽HBD-2、HBD-3及LL-37mRNA的表达。方法应用逆转录(RT-PCR)方法检测56例尖锐湿疣患者皮损和30名正常人皮肤组织中HBD-2、HBD-3及LL-37mRNA的表达。结果：与正常人皮肤组织相比，尖锐湿疣患者皮损中HBD-2、HBD-3及LL-37mRNA的表达水平明显升高(P<0.05)。结论：尖锐湿疣患者皮损中HBD-2、HBD-3及LL-37mRNA表达水平的上调可能与尖锐湿疣患者局部产生免疫防御有关。
目的：檢測尖銳濕疣患者皮損中抗菌肽HBD-2、HBD-3及LL-37mRNA的錶達。方法應用逆轉錄(RT-PCR)方法檢測56例尖銳濕疣患者皮損和30名正常人皮膚組織中HBD-2、HBD-3及LL-37mRNA的錶達。結果：與正常人皮膚組織相比，尖銳濕疣患者皮損中HBD-2、HBD-3及LL-37mRNA的錶達水平明顯升高(P<0.05)。結論：尖銳濕疣患者皮損中HBD-2、HBD-3及LL-37mRNA錶達水平的上調可能與尖銳濕疣患者跼部產生免疫防禦有關。
목적：검측첨예습우환자피손중항균태HBD-2、HBD-3급LL-37mRNA적표체。방법응용역전록(RT-PCR)방법검측56례첨예습우환자피손화30명정상인피부조직중HBD-2、HBD-3급LL-37mRNA적표체。결과：여정상인피부조직상비，첨예습우환자피손중HBD-2、HBD-3급LL-37mRNA적표체수평명현승고(P<0.05)。결론：첨예습우환자피손중HBD-2、HBD-3급LL-37mRNA표체수평적상조가능여첨예습우환자국부산생면역방어유관。
Objective:To investigate the mRNA expression of antimicrobial peptide HBD-2, HBD-3 and LL-37 in the patients with condyloma acuminatum ( CA) . Methods:The skin biopsies were taken from skin lesions in 56 patients with CA and 30 normal controls. Reverse transcriptase-polymerase chain reaction ( RT-PCR) was used to semi-quantitatively analyze the mRNA expression of HBD-2, HBD-3 and LL-37 in the tissue samples. Results:The mRNA expressions of HBD-2, HBD-3 and LL-37 were significant higher in CA than in the normal controls ( P<0.05) . Conclusion:Up-regulated expression of HBD-2, HBD-3 and LL-37 may be related to local immune defense of CA.
