中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2014年
2期
153-154
,共2页
朱长琪%杨静%孟令毅%夏家栋
硃長琪%楊靜%孟令毅%夏傢棟
주장기%양정%맹령의%하가동
冠心病%尿酸%危险因素
冠心病%尿痠%危險因素
관심병%뇨산%위험인소
Coronary disease%Uric acid%Risk factors
目的：探讨血尿酸水平和冠心病慢性心功能不全的关系。方法将296例冠心病患者分为两组：心功能正常组173例，心功能不全组123例，心功能不全组按纽约心脏病学会NYHA分级分为心功能Ⅱ级组（n＝31），心功能Ⅲ级组（n＝40），心功能Ⅳ级组（n＝52）。应用尿酸氧化酶法测定血尿酸浓度。结果①心功能正常组血尿酸浓度（330．62±89．21）μmol/L，高尿酸血症发生率21．97％；心功能不全组血尿酸浓度（415．63±100．30）μmol/L，高尿酸血症发生率50．41％（P＜0．01）。②心功能Ⅱ级亚组血尿酸浓度（362．37±101．01）μmol/L，高尿酸血症发生率25．81％；心功能Ⅲ级亚组血尿酸浓度（389．12±100．37）μmol/L，高尿酸血症发生率35．00％；心功能Ⅳ级亚组血尿酸浓度（427．21±98．33）μmol/L，高尿酸血症发生率82．69％；各组间血尿酸水平差异有统计学意义（P＜0．05）。结论冠心病慢性心功能不全患者血尿酸水平升高，血尿酸水平与心功能不全的严重程度呈正相关。
目的：探討血尿痠水平和冠心病慢性心功能不全的關繫。方法將296例冠心病患者分為兩組：心功能正常組173例，心功能不全組123例，心功能不全組按紐約心髒病學會NYHA分級分為心功能Ⅱ級組（n＝31），心功能Ⅲ級組（n＝40），心功能Ⅳ級組（n＝52）。應用尿痠氧化酶法測定血尿痠濃度。結果①心功能正常組血尿痠濃度（330．62±89．21）μmol/L，高尿痠血癥髮生率21．97％；心功能不全組血尿痠濃度（415．63±100．30）μmol/L，高尿痠血癥髮生率50．41％（P＜0．01）。②心功能Ⅱ級亞組血尿痠濃度（362．37±101．01）μmol/L，高尿痠血癥髮生率25．81％；心功能Ⅲ級亞組血尿痠濃度（389．12±100．37）μmol/L，高尿痠血癥髮生率35．00％；心功能Ⅳ級亞組血尿痠濃度（427．21±98．33）μmol/L，高尿痠血癥髮生率82．69％；各組間血尿痠水平差異有統計學意義（P＜0．05）。結論冠心病慢性心功能不全患者血尿痠水平升高，血尿痠水平與心功能不全的嚴重程度呈正相關。
목적：탐토혈뇨산수평화관심병만성심공능불전적관계。방법장296례관심병환자분위량조：심공능정상조173례，심공능불전조123례，심공능불전조안뉴약심장병학회NYHA분급분위심공능Ⅱ급조（n＝31），심공능Ⅲ급조（n＝40），심공능Ⅳ급조（n＝52）。응용뇨산양화매법측정혈뇨산농도。결과①심공능정상조혈뇨산농도（330．62±89．21）μmol/L，고뇨산혈증발생솔21．97％；심공능불전조혈뇨산농도（415．63±100．30）μmol/L，고뇨산혈증발생솔50．41％（P＜0．01）。②심공능Ⅱ급아조혈뇨산농도（362．37±101．01）μmol/L，고뇨산혈증발생솔25．81％；심공능Ⅲ급아조혈뇨산농도（389．12±100．37）μmol/L，고뇨산혈증발생솔35．00％；심공능Ⅳ급아조혈뇨산농도（427．21±98．33）μmol/L，고뇨산혈증발생솔82．69％；각조간혈뇨산수평차이유통계학의의（P＜0．05）。결론관심병만성심공능불전환자혈뇨산수평승고，혈뇨산수평여심공능불전적엄중정도정정상관。
Objective To investigate the relationship between serum uric acid and chronic cardiac insuffi-ciency of patients with coronary heart diseases.Methods Patients with coronary heart diseases were divided into 2 groups:normal cardiac function group(173cases)and cardiac dysfunction group(123cases).According to the New York Heart Association(NYHA)criteria,a total of 173 cardiac dysfunction patients were divided into Group NYHAⅡ(n=31),Group NYHAⅢ(n=40),Group NYHAⅣ(n=52),The level of SUA was measured with urate oxidase method.Results (1)The mean SUA level in normal cardiac function group was(330.62 ±89.21)μmol/L,and the total incidence of hyperuricemia(HUA)was 21.97%.The mean SUA level in cardiac dysfunction group was (415.63 ±100.30)μmol/L,and the total incidence of HUA was 50.41%.(2)The mean SUA level in patients with NYHAⅡ,NYHA Ⅲ,NYHA Ⅳwas (362.37 ±101.01)μmol/L,(389.12 ±100.37)μmol/L,and (427.21 ±98.33)μmol/L respectively,and the incidences of HUA were 25.81%,35.00%,and 82.69%respectively.There was signif-icant difference in SUA among these groups(P<0.05 ).Conclusion The mean SUA level in patients with cardiac dysfunction is higher than patients with normal cardiac function.There is a positive correlation between the level of SUA and the severity of cardiac dysfunction.
