CAJ | 학술논문

目的：评价盐酸多奈哌齐联合脑蛋白水解物注射液和银杏叶提取物对阿尔茨海默病患者认知功能、日常行为功能障碍的改善作用。方法收集132例患者随机分为2个组，盐酸多奈哌齐联合脑蛋白水解物和银杏叶提取物治疗组66例（联合治疗组），盐酸多奈哌齐治疗组66例（盐酸多奈哌齐组），2个组年龄、性别及病情等一般情况差异无统计学意义。两组患者分别在治疗前、治疗后3、6、12个月进行简易智能精神状态MMSE量表、日常生活功能ADL量表的测评。治疗前、治疗中和治疗结束后均检测肝肾功和心电图。结果盐酸多奈哌齐联合脑蛋白水解物和银杏叶提取物治疗组治疗阿尔茨海默病患者3个月、6个月和12个月后，认知功能的改善和行为能力的改善均明显好于盐酸多奈哌齐治疗组（P＜0．01）。结论盐酸多奈哌齐联合脑蛋白水解物和银杏叶提取物联合应用改善阿尔茨海默病认知功能和行为能力的效果优于单用盐酸多奈哌齐，且无明显副作用。
목적：평개염산다내고제연합뇌단백수해물주사액화은행협제취물대아이자해묵병환자인지공능、일상행위공능장애적개선작용。방법수집132례환자수궤분위2개조，염산다내고제연합뇌단백수해물화은행협제취물치료조66례（연합치료조），염산다내고제치료조66례（염산다내고제조），2개조년령、성별급병정등일반정황차이무통계학의의。량조환자분별재치료전、치료후3、6、12개월진행간역지능정신상태MMSE량표、일상생활공능ADL량표적측평。치료전、치료중화치료결속후균검측간신공화심전도。결과염산다내고제연합뇌단백수해물화은행협제취물치료조치료아이자해묵병환자3개월、6개월화12개월후，인지공능적개선화행위능력적개선균명현호우염산다내고제치료조（P＜0．01）。결론염산다내고제연합뇌단백수해물화은행협제취물연합응용개선아이자해묵병인지공능화행위능력적효과우우단용염산다내고제，차무명현부작용。
Objective To investigate the effect of Donepezil combined with Cerebrolysin(CL)and Ginkgo biloba(Egb76 1 )in the treatment of aged patients with Alzheimer's disease on cognitive function and behavioral disor-ders.Methods A total of 132 patients with Alzheimer's disease were collected and randomly divided into 2 groups:Donepezil combined with Cerebrolysin(CL)and Ginkgo biloba(Egb761)group (combined treatment group,n=66), Donepezil group(n=66).MMSE Scale and ADL Scale of 2 groups were assessed and compared before treatment and 3 months,6 months and 12 months after treatment.Results The cognitive function and behavioral abilities in aged patients with Alzheimer's disease improved markedly (P<0.01 )in the combined group 3 months,6months and 12 months after treatment.Conclusion Combination of Donepezil with Cerebrolysin(CL)and Ginkgo biloba(Egb761 ) can markedly ameliorate the cognitive function and behavioral abilities in patients with Alzheimer's disease with no ob-vious side effects.