CAJ | 학술논문

目的：观察神经节苷脂联合丹参酮对急性脑梗死患者的治疗效果。方法急性脑梗死患者86例，按病例对照研究的方法分组，对照组43例，以丹参酮注射液30 mL＋5％葡萄糖注射液250 mL静脉滴注，1次/d，共14 d；联合治疗组43例，在丹参酮治疗基础上联合以神经节苷脂80 mg＋5％葡萄糖注射液250 mL静脉滴注，1次/d，共14 d。两组基础用药治疗相同。比较两组患者于治疗前、后神经功能缺损程度（NIHSS）及日常生活活动量（ADL）评分，并进行疗效评定。结果联合治疗组在治疗后14 d NIHSS评分及ADL评分与对照组相比，差异有统计学意义（P＜0．05）；治疗组临床疗效明显优于对照组（P＜0．05），其神经功能缺损程度明显改善，日常生活能力明显提高。结论神经节苷脂联合丹参酮能更好地改善急性脑梗死患者的预后，降低患者的神经功能的缺损程度。
목적：관찰신경절감지연합단삼동대급성뇌경사환자적치료효과。방법급성뇌경사환자86례，안병례대조연구적방법분조，대조조43례，이단삼동주사액30 mL＋5％포도당주사액250 mL정맥적주，1차/d，공14 d；연합치료조43례，재단삼동치료기출상연합이신경절감지80 mg＋5％포도당주사액250 mL정맥적주，1차/d，공14 d。량조기출용약치료상동。비교량조환자우치료전、후신경공능결손정도（NIHSS）급일상생활활동량（ADL）평분，병진행료효평정。결과연합치료조재치료후14 d NIHSS평분급ADL평분여대조조상비，차이유통계학의의（P＜0．05）；치료조림상료효명현우우대조조（P＜0．05），기신경공능결손정도명현개선，일상생활능력명현제고。결론신경절감지연합단삼동능경호지개선급성뇌경사환자적예후，강저환자적신경공능적결손정도。
Objective To observe the effects of ganglioside GM1 combined with sodium tanshinone sulpho-nate IIA in the treatment of acute cerebral infarction(ACI).Mehtods 86 cases with ACI were randomly divided in-to two groups.43 cases in the control group were treated with sodium tanshinone sulphonate IIA 30 mL and 5% GS 250 ml iv gtt,qd for 14 days.43 cases in the combined treatment group were treated with GM1 80 mg and 5%GS 250 mL iv gtt,qd for 14 days;as w ell as sodium tanshinone sulphonate IIA 30 mL and 5% GS 250 mL iv gtt,qd for 14 days.The conventional treatments in two groups were the same.The neurological impairment scores(NIHSS)and ac-tivity of daily living(ADL)scale were evaluated and compared before and after treatmen.Results In combined treat-ment group,there were significant differences in NIHSS and ADL between treatment group and control group after 14 days treatment(P<0.05).The clinical curative rate in combined treatment group was significantly higher than that in control group(P<0.05).Both the neurological impairment score and capability for daily living improved obviously. Conclusion Ganglioside GM 1 combined with sodium tanshinone sulphonate IIA can improve the prognosis of the patients with ACI preferably and lighten the neural function deficience.