中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2014年
2期
124-127
,共4页
米力克扎提·吾甫尔%木胡牙提·乌拉斯汉
米力剋扎提·吾甫爾%木鬍牙提·烏拉斯漢
미력극찰제·오보이%목호아제·오랍사한
心房颤动%多态现象,遗传%华法林%汉族
心房顫動%多態現象,遺傳%華法林%漢族
심방전동%다태현상,유전%화법림%한족
Atrial fibrillation%Polymorphism,Genetic%Warfarin%Han nationality
目的：研究汉族GGCX基因rs11676382位点多态性与心房颤动（AF）的相关性。方法以200例汉族未服用华法林的心房颤动患者作为研究组，200例健康汉族患者作为对照组，所有患者均采集外周血提取基因组 DNA，采用聚合酶链反应，限制性片段长度多态性技术（PCRRFLP ）检查患者 GGCX 基因rs11676382多态性的基因型和等位基因频率分布，观察GGCX基因rs11676382多态性与心房颤动的关系。结果 GGCX基因rs11676382位点在入选人群中的基因型及等位基因分别为CC、CG和GG型，其基因型频率在心房颤动组和对照组分别依次为82．5％、16．5％、1．0％和85．0％、0．5％、14．5％，分布趋势相同，差异无统计学意义（P＞0．05）；C和G等位基因频率在心房颤动组和对照组分别为99．0％，1．0％和99．5％，0．5％，C和G等位基因频率在两组间的差异无统计学意义（P＞0．05）。结论 GGCX基因rs11676382多态性与未服用华法林的心房颤动无相关性。
目的：研究漢族GGCX基因rs11676382位點多態性與心房顫動（AF）的相關性。方法以200例漢族未服用華法林的心房顫動患者作為研究組，200例健康漢族患者作為對照組，所有患者均採集外週血提取基因組 DNA，採用聚閤酶鏈反應，限製性片段長度多態性技術（PCRRFLP ）檢查患者 GGCX 基因rs11676382多態性的基因型和等位基因頻率分佈，觀察GGCX基因rs11676382多態性與心房顫動的關繫。結果 GGCX基因rs11676382位點在入選人群中的基因型及等位基因分彆為CC、CG和GG型，其基因型頻率在心房顫動組和對照組分彆依次為82．5％、16．5％、1．0％和85．0％、0．5％、14．5％，分佈趨勢相同，差異無統計學意義（P＞0．05）；C和G等位基因頻率在心房顫動組和對照組分彆為99．0％，1．0％和99．5％，0．5％，C和G等位基因頻率在兩組間的差異無統計學意義（P＞0．05）。結論 GGCX基因rs11676382多態性與未服用華法林的心房顫動無相關性。
목적：연구한족GGCX기인rs11676382위점다태성여심방전동（AF）적상관성。방법이200례한족미복용화법림적심방전동환자작위연구조，200례건강한족환자작위대조조，소유환자균채집외주혈제취기인조 DNA，채용취합매련반응，한제성편단장도다태성기술（PCRRFLP ）검사환자 GGCX 기인rs11676382다태성적기인형화등위기인빈솔분포，관찰GGCX기인rs11676382다태성여심방전동적관계。결과 GGCX기인rs11676382위점재입선인군중적기인형급등위기인분별위CC、CG화GG형，기기인형빈솔재심방전동조화대조조분별의차위82．5％、16．5％、1．0％화85．0％、0．5％、14．5％，분포추세상동，차이무통계학의의（P＞0．05）；C화G등위기인빈솔재심방전동조화대조조분별위99．0％，1．0％화99．5％，0．5％，C화G등위기인빈솔재량조간적차이무통계학의의（P＞0．05）。결론 GGCX기인rs11676382다태성여미복용화법림적심방전동무상관성。
Objective To investigate the Correlation between the rs1 1676382 polymorphism of GGCX gene with atrial fibrillation (AF)in Han Chinese in Xinjiang.Methods There were 200 Han Chinese patients who not taking warfarin with atrial fibrillation were collected as study group,and 200 healthy cases were collected as control group.The DNA of peripheral venous blood was extracted.The rs1 1676382 polymorphism of GGCX gene were detected by polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP).The GGCX genotype and allele distribution were analyzed.Result The GGCX genotype were CC,CG and GG,and the genetype frequency in the study group was 82.5%,16.5% and 1%,and 15.85%,14.5%,0.5% in the control group.There were no significant differences in the genotype distribution of Rs1 1676382 GGCX gene loci in the Han Chinese between the study group and the control group (P>0.05);The allele C and G frequencies were 99%and1%in the study group, 99.5% and 0.5%,in the control group.There were no statistical significance in the allele C and G frequencies be-tween the two groups(P>0.05 ).Conclusion There are no correlation between the GGCX gene rs1 1676382 poly-morphism and atrial fibrillation in the patients who were not taking warfarin.
