CAJ | 학술논문

目的：观察补阳还五汤联合低分子肝素钙注射液治疗剖宫产术后下肢深静脉血栓(DVT)形成患者的效果。方法选取剖宫产术后 DVT 形成患者76例,随机分为2组。对照组36例,予低分子肝素钙注射液,100 AXaIU/kg,皮下注射,每日2次；治疗组40例,在对照组治疗基础上予补阳还五汤。观察治疗前后临床症状、体征及全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)、纤维蛋白原(FIB)、血小板(PLT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)及阻抗容积波图指标、彩色多普勒血流显像(CDFI)。结果治疗后治疗组总有效率为97.5%(39/40),对照组为77.8%(28/36),差异有统计学意义(P＜0.05)。治疗组血液流变学(HBV、LBV、PV、FIB)及阻抗容积波图指标治疗前后比较,差异有统计学意义(P＜0.05),治疗组凝血功能指标(APTT、TT、PT)治疗前后差异无统计学意义(P＞0.05)。治疗期间未发生不良反应。结论补阳还五汤联合低分子肝素钙注射液治疗剖宫产术后DVT形成安全有效。
목적：관찰보양환오탕연합저분자간소개주사액치료부궁산술후하지심정맥혈전(DVT)형성환자적효과。방법선취부궁산술후 DVT 형성환자76례,수궤분위2조。대조조36례,여저분자간소개주사액,100 AXaIU/kg,피하주사,매일2차；치료조40례,재대조조치료기출상여보양환오탕。관찰치료전후림상증상、체정급전혈고절점도(HBV)、전혈저절점도(LBV)、혈장점도(PV)、섬유단백원(FIB)、혈소판(PLT)、부분응혈활매시간(APTT)、응혈매시간(TT)、응혈매원시간(PT)급조항용적파도지표、채색다보륵혈류현상(CDFI)。결과치료후치료조총유효솔위97.5%(39/40),대조조위77.8%(28/36),차이유통계학의의(P＜0.05)。치료조혈액류변학(HBV、LBV、PV、FIB)급조항용적파도지표치료전후비교,차이유통계학의의(P＜0.05),치료조응혈공능지표(APTT、TT、PT)치료전후차이무통계학의의(P＞0.05)。치료기간미발생불량반응。결론보양환오탕연합저분자간소개주사액치료부궁산술후DVT형성안전유효。
Objective To observe the treatment effect of Buyang Huanwu Decoction combined with low molecular weight heparin calcium injection in treating deep venous thrombosis (DVT) in lower limb after cesarean section. Methods Seventy-six cases of DVT after cesarean were randomly divided into 2 groups. Thirty-six cases of control group were injected low molecular weight heparin calcium subcutaneously 100 AXaIU/kg twice daily, and forty cases of treatment group were treated with Buyang Huanwu Decoction additionally. After analysing the clinical symptoms and sign before and after treatment, HBV, LBV, PV, FIB, PLT, APTT, TT, PT and indexes of impedance plethysmography, CDFI were observed to evaluate the efficacy. Results After treatment, the total effective rate of treatment group was 97.5%(39/40), and the control group was 77.8%(28/36), the difference was statistically significant (P<0.05). The differences of hemorheological indexes (HBV, LBV, PV, FIB) and impedance plethysmography indexes between before and after treatment in treatment group were statistically significant (P<0.05), while the differences of blood coagulation indexes (APTT, TT, PT) were not significant (P>0.05). No adverse reaction was found during treatment. Conclusion The treatment of DVT after cesarean section with Buyang Huanwu Decoction combined with low molecular weight heparin calcium injection is safe and effective.