CAJ | 학술논문

目的：观察文达敏治疗2型糖尿病的疗效与安全性。方法选择120例应用较大剂量胰岛素（诺和锐30）血糖及糖化血红蛋白仍控制不佳的2型糖尿病患者，给予文达敏治疗12周，比较治疗前后患者空腹血糖、餐后2小时血糖、空腹胰岛素、餐后2小时胰岛素、糖化血红蛋白、腰围、体重指数（BMI）及全天胰岛素用量指标，并计算胰岛素抵抗（IR）指数（HOMA - IR）、胰岛素敏感指数（ISI）、胰岛β细胞分泌功能指数（HOMA - IS）。结果治疗后患者的糖化血红蛋白、空腹血糖、餐后2小时血糖、空腹胰岛素、餐后2小时胰岛素显著降低（P <0.05）；BMI、腰围稍有增加，差异无统计学意义（ P >0.05）；HOMA - IR 显著降低，HOMA -IS、ISI 升高（P <0.01），并且全天胰岛素用量明显下降（P <0.01）。结论文达敏能显著降低2型糖尿病患者的血糖、糖化血红蛋白，并且能减轻 IR，增加胰岛素敏感性，恢复胰岛β细胞功能，减少全天胰岛素的用量。
목적：관찰문체민치료2형당뇨병적료효여안전성。방법선택120례응용교대제량이도소（낙화예30）혈당급당화혈홍단백잉공제불가적2형당뇨병환자，급여문체민치료12주，비교치료전후환자공복혈당、찬후2소시혈당、공복이도소、찬후2소시이도소、당화혈홍단백、요위、체중지수（BMI）급전천이도소용량지표，병계산이도소저항（IR）지수（HOMA - IR）、이도소민감지수（ISI）、이도β세포분비공능지수（HOMA - IS）。결과치료후환자적당화혈홍단백、공복혈당、찬후2소시혈당、공복이도소、찬후2소시이도소현저강저（P <0.05）；BMI、요위초유증가，차이무통계학의의（ P >0.05）；HOMA - IR 현저강저，HOMA -IS、ISI 승고（P <0.01），병차전천이도소용량명현하강（P <0.01）。결논문체민능현저강저2형당뇨병환자적혈당、당화혈홍단백，병차능감경 IR，증가이도소민감성，회복이도β세포공능，감소전천이도소적용량。
Objective To observe the efficacy and safety of avandamet in the treatment of Patients with tyPe 2 diabetes. Methods 120 Patients with tyPe 2 diabetes using large dose of insulin(AsPart 30)with bad control of blood sugar and glycosylated hemoglobin were enrolled. Each Patient was treated with avandamet for 12 weeks. Fasting Plas-ma glucose,two - hour PostPrandial Plasma glucose,fasting insulin,two - hour fasting insulin,glycosylated hemoglo-bin,waist,body mass index(BMI)and insulin dosage throughout the day were comPared before and after treatment. HOMA - insulin resistance index(HOMA - IR),HOMA - insulin sensitive index(ISI)and HOMA - insulin secretion (HOMA - IS)were calculated. Results Glycosylated hemoglobin,fasting Plasma glucose,two - hour PostPrandial Plasma glucose,fasting insulin,two - hour fasting insulin significantly decreased after treatment(P < 0. 05). BMI and waist increased slightly(P > 0. 05). HOMA - IR decreased significantly,and HOMA - IS and ISI increased(P < 0. 01). Insulin dosage throughout the day decreased significantly(P < 0. 01). Conclusions Avandamet can significantly reduce blood glucose and glycosylated hemoglobin. It can also alleviate insulin resistance,increase insulin sensitivity, restore the function of islet β cells,and decrease insulin dosage throughout the day.