健康之路
健康之路
건강지로
HEALTH
2014年
4期
42-42
,共1页
慢性阻塞性肺疾病%血小板活化因子%急性加重期
慢性阻塞性肺疾病%血小闆活化因子%急性加重期
만성조새성폐질병%혈소판활화인자%급성가중기
Chronic obstructive pulmonary disease%Platelet activating factor%Acute exacerbation
目的：对慢性阻塞性肺疾病(COPD)患者的血浆血小板中 CD62P、CD63、CD41、CD61活化指标进行严密观察，并深入探讨在 COPD 发生发展过程中血小板聚集的功能变化发挥的作用及其临床意义。方法：运用流式细胞术对64例 COPD 患者的血小板活化指标进行测定，并比较治疗前后患者指标变化量，再与32例健康对照组进行比较。结果：血浆中的 CD62P、CD63急性期组患者高于对照组及缓解期组；血浆中 CD62P、CD63缓解期组患者高于对照组；血浆中 CD41、CD61急性期组患者与缓解期组比较差异不具有统计学意义。结论：随着 COPD 患者血小板活化程度提高，急性期患者血小板活化程度显著增高；并推测出在 COPD 发生发展的过程中血小板活化程度增高起着重要作用。
目的：對慢性阻塞性肺疾病(COPD)患者的血漿血小闆中 CD62P、CD63、CD41、CD61活化指標進行嚴密觀察，併深入探討在 COPD 髮生髮展過程中血小闆聚集的功能變化髮揮的作用及其臨床意義。方法：運用流式細胞術對64例 COPD 患者的血小闆活化指標進行測定，併比較治療前後患者指標變化量，再與32例健康對照組進行比較。結果：血漿中的 CD62P、CD63急性期組患者高于對照組及緩解期組；血漿中 CD62P、CD63緩解期組患者高于對照組；血漿中 CD41、CD61急性期組患者與緩解期組比較差異不具有統計學意義。結論：隨著 COPD 患者血小闆活化程度提高，急性期患者血小闆活化程度顯著增高；併推測齣在 COPD 髮生髮展的過程中血小闆活化程度增高起著重要作用。
목적：대만성조새성폐질병(COPD)환자적혈장혈소판중 CD62P、CD63、CD41、CD61활화지표진행엄밀관찰，병심입탐토재 COPD 발생발전과정중혈소판취집적공능변화발휘적작용급기림상의의。방법：운용류식세포술대64례 COPD 환자적혈소판활화지표진행측정，병비교치료전후환자지표변화량，재여32례건강대조조진행비교。결과：혈장중적 CD62P、CD63급성기조환자고우대조조급완해기조；혈장중 CD62P、CD63완해기조환자고우대조조；혈장중 CD41、CD61급성기조환자여완해기조비교차이불구유통계학의의。결론：수착 COPD 환자혈소판활화정도제고，급성기환자혈소판활화정도현저증고；병추측출재 COPD 발생발전적과정중혈소판활화정도증고기착중요작용。
Objective:In chronic obstructive pulmonary disease(COPD)of plasma platelet in patients with CD62P,CD63 ,CD41 ,CD6 1 activation markers were closely observed,and in-depth study of changes of platelet aggregation in the process of development in COPD and itsclinical significance.Methods:The use of platelet in 64 pa-tients with COPD activation index were measured by flow cytometry,and compare the changes in patients before and after treatment,and compared with 32 healthy control group.Result:Plasma CD62P and CD63 in acute stage patients is higher than the control group and the remission group;Plasma CD62P and CD63 in remission group of pa-tients is higher than the control group;CD41 ,CD6 1 in plasma in patients with acute phase of the group no statistical y significant difference compared with remission group.Conclusion:With increased platelet activation in patients with COPD,the acute phase of the degree of platelet activation in patients with significantly higher;In the process of occurrence and development of COPD and draw the increased level of platelet activation plays an important role.
