CAJ | 학술논문

目的：探讨度洛西汀治疗心脏神经症的临床疗效及安全性。方法将92例心脏神经症患者随机分为两组，每组46例，两组均口服谷维素及普萘洛尔治疗，观察组在此基础上联合度洛西汀治疗，观察8周。于治疗前后采用汉密顿焦虑量表、汉密顿抑郁量表评定焦虑抑郁状况，根据症状改善程度判定临床疗效。结果观察组总有效率为93．5％，对照组为78．3％，观察组总有效率显著高于对照组（P＜0．05）；治疗后两组汉密顿焦虑量表、汉密顿抑郁量表评分均较治疗前显著降低（P＜0．01），观察组显著低于对照组（P＜0．01）；两组不良反应均轻微。结论度洛西汀治疗心脏神经症疗效显著，安全性高。
목적：탐토도락서정치료심장신경증적림상료효급안전성。방법장92례심장신경증환자수궤분위량조，매조46례，량조균구복곡유소급보내락이치료，관찰조재차기출상연합도락서정치료，관찰8주。우치료전후채용한밀돈초필량표、한밀돈억욱량표평정초필억욱상황，근거증상개선정도판정림상료효。결과관찰조총유효솔위93．5％，대조조위78．3％，관찰조총유효솔현저고우대조조（P＜0．05）；치료후량조한밀돈초필량표、한밀돈억욱량표평분균교치료전현저강저（P＜0．01），관찰조현저저우대조조（P＜0．01）；량조불량반응균경미。결론도락서정치료심장신경증료효현저，안전성고。
Objective To explore the efficacy and safety of duloxetine in the treatment of cardiac neurosis .Methods Ninety-two patients with cardiac neurosis were randomly divided into 2 groups of 46 ones each , both groups took orally oryzanol and propranolol ,on this basis observation group was plus duloxetine for 8 weeks .Anxiety-depression status was assessed with the Hamilton Anxiety Scale (HAMA) and Hamil-ton Depression Scale (HAMD) before and after treatment ,efficacies were determined according to symp-tom improvement degree .Results Total effective rate was significantly higher in observation than control group (93 .5% vs .78 .3% ,P<0 .05);after treatment the HAMA and HAMD scores of both groups low-ered more significantly compared with pre-treatment (P<0 .01) ,so did that in observation than control group (93 .5% vs .78 .3% ,P<0 .05);adverse reactions of both groups were mild .Conclusion Duloxe-tine has an evident effect and higher safety in the treatment of cardiac neurosis .