CAJ | 학술논문

目的：探讨不同剂量地塞米松（DXM）治疗小儿重症病毒性脑炎（SVE）的临床疗效。方法选取2010年1月～2012年12月广东省深圳市宝安区妇幼保健院就诊的80例SVE患儿的临床资料行回顾性分析，根据治疗中使用DXM剂量不同分组，比较疗效及不良反应。结果大剂量组近期疗效优良率显著高于短程小剂量组，差异有统计学意义（P<0.05），意识障碍、抽搐、脑膜刺激征等恢复时间及住院时间均显著减少，差异有统计学意义（P<0.05）；大、小剂量组分别有6例（15%）和5例（13.2%）并发消化道出血，差异无统计学意义。结论在小儿DXM治疗中，大剂量短程DXM的应用，近期疗效观察可行、有效且安全。
목적：탐토불동제량지새미송（DXM）치료소인중증병독성뇌염（SVE）적림상료효。방법선취2010년1월～2012년12월광동성심수시보안구부유보건원취진적80례SVE환인적림상자료행회고성분석，근거치료중사용DXM제량불동분조，비교료효급불량반응。결과대제량조근기료효우량솔현저고우단정소제량조，차이유통계학의의（P<0.05），의식장애、추휵、뇌막자격정등회복시간급주원시간균현저감소，차이유통계학의의（P<0.05）；대、소제량조분별유6례（15%）화5례（13.2%）병발소화도출혈，차이무통계학의의。결론재소인DXM치료중，대제량단정DXM적응용，근기료효관찰가행、유효차안전。
Objective To study the different doses of dexamethasone (DXM) in treatment of children with severe viral encephalitis (SVE) of clinical efifcacy. Method From January 2010 to December 2012 in the hospital were retrospectively analyzed the clinical data of 80 cases of children with SVE line, depending on the dose DXM used in the treatment group, curative effect and adverse reactions. Results compared with short range small dose group. Results Iarge dose group the recent curative effect was signiifcantly higher (P<0.05), the disturbance of consciousness and convulsions, and meningeal stimulation recovery time and hospital stay were signiifcantly shorter (P<0.05);Large and small dose group there were 6 cases (15%) and 5 cases (13.2%) complicated with alimentary tract hemorrhage. Conclusion In infantile DXM treatment, application of high-dose short-range DXM, recent curative effect observation of feasible, effective and safe.