中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
10期
1635-1640
,共6页
干细胞%移植%胚胎干细胞%骨髓间充质干细胞%诱导性多能干细胞%糖尿病肾病
榦細胞%移植%胚胎榦細胞%骨髓間充質榦細胞%誘導性多能榦細胞%糖尿病腎病
간세포%이식%배태간세포%골수간충질간세포%유도성다능간세포%당뇨병신병
stem cells%diabetic nephropathies%mesenchymal stem cells%multipotent stem cells
背景：糖尿病肾病的治疗思路主要集中在控制血糖、血压、血脂等危险因素以及抑制肾素-血管紧张素系统，但治疗效果并不理想。病情严重者可接受血液透析和肾移植，但肾源有限，费用昂贵，限制了其发展。以干细胞为基础的再生医学研究有可能为糖尿病肾病的治疗带来新的希望。<br> 目的：综合分析不同来源干细胞治疗糖尿病肾病的机制及临床研究进展。<br> 方法：应用计算机检索CNKI 和PubMed 数据库中2005年1月至2013年8月关于干细胞治疗糖尿病肾病的文章，在标题和中以“胚胎干细胞；骨髓间充质干细胞；诱导性多能干细胞；糖尿病肾病”或embryonic stem cel s； bone marrow mesenchymal stem cel s； induced poluripotent stem cel s； induced multipotent stem cel s；diabetic nephropathy”为检索词进行检索。最终选择60篇文章进行综述。<br> 结果与结论：大量研究表明干细胞移植对肾脏损伤和修复具有积极的作用，诱导性多能干细胞、胚胎干细胞、骨髓间充质干细胞均具有向肾脏组织细胞分化的潜能，干细胞移植有可能为糖尿病肾病提供一种新型的治疗方案。
揹景：糖尿病腎病的治療思路主要集中在控製血糖、血壓、血脂等危險因素以及抑製腎素-血管緊張素繫統，但治療效果併不理想。病情嚴重者可接受血液透析和腎移植，但腎源有限，費用昂貴，限製瞭其髮展。以榦細胞為基礎的再生醫學研究有可能為糖尿病腎病的治療帶來新的希望。<br> 目的：綜閤分析不同來源榦細胞治療糖尿病腎病的機製及臨床研究進展。<br> 方法：應用計算機檢索CNKI 和PubMed 數據庫中2005年1月至2013年8月關于榦細胞治療糖尿病腎病的文章，在標題和中以“胚胎榦細胞；骨髓間充質榦細胞；誘導性多能榦細胞；糖尿病腎病”或embryonic stem cel s； bone marrow mesenchymal stem cel s； induced poluripotent stem cel s； induced multipotent stem cel s；diabetic nephropathy”為檢索詞進行檢索。最終選擇60篇文章進行綜述。<br> 結果與結論：大量研究錶明榦細胞移植對腎髒損傷和脩複具有積極的作用，誘導性多能榦細胞、胚胎榦細胞、骨髓間充質榦細胞均具有嚮腎髒組織細胞分化的潛能，榦細胞移植有可能為糖尿病腎病提供一種新型的治療方案。
배경：당뇨병신병적치료사로주요집중재공제혈당、혈압、혈지등위험인소이급억제신소-혈관긴장소계통，단치료효과병불이상。병정엄중자가접수혈액투석화신이식，단신원유한，비용앙귀，한제료기발전。이간세포위기출적재생의학연구유가능위당뇨병신병적치료대래신적희망。<br> 목적：종합분석불동래원간세포치료당뇨병신병적궤제급림상연구진전。<br> 방법：응용계산궤검색CNKI 화PubMed 수거고중2005년1월지2013년8월관우간세포치료당뇨병신병적문장，재표제화중이“배태간세포；골수간충질간세포；유도성다능간세포；당뇨병신병”혹embryonic stem cel s； bone marrow mesenchymal stem cel s； induced poluripotent stem cel s； induced multipotent stem cel s；diabetic nephropathy”위검색사진행검색。최종선택60편문장진행종술。<br> 결과여결론：대량연구표명간세포이식대신장손상화수복구유적겁적작용，유도성다능간세포、배태간세포、골수간충질간세포균구유향신장조직세포분화적잠능，간세포이식유가능위당뇨병신병제공일충신형적치료방안。
BACKGROUND:To control blood glucose, blood pressure, blood lipids and inhibit the rennin-angiotensin system is the main idea focused on the treatment of diabetic nephropathy, but the curative effect is unsatisfactory. Hemodialysis and kidney transplantation are suitable for serious cases, however, which is restricted because of the limited source of kidneys and high cost. Regenerative medicine research based on stem cells brings a new hope for treatment of diabetic nephropathy. OBJECTIVE:To comprehensively analyze the mechanism underlying different sources of stem cells for treatment of diabetic nephropathy and the clinical implications. METHODS:Papers addressing stem cells for the treatment of diabetic nephropathy were retrieved by computer in CNKI database and PubMed database from January 2005 to August 2013 with the key words“embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells, diabetic nephropathy"in Chinese and English. Papers published recently or in journals with high impact factor were selected. A total of 60 papers were included for review. RESULTS AND CONCLUSION:Embryonic stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells have the potential to differentiate into renal histiocytes. A large numbers of experimental studies have shown that stem cells transplantation has a positive effect on recovery of injured kidney. Stem celltransplantation can provide a novel therapy for diabetic nephropathy.
