中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
13期
2096-2103
,共8页
植入物%脊柱植入物%射频热凝靶点消融术%臭氧%腰椎间盘突出症%Meta分析%随机对照试验
植入物%脊柱植入物%射頻熱凝靶點消融術%臭氧%腰椎間盤突齣癥%Meta分析%隨機對照試驗
식입물%척주식입물%사빈열응파점소융술%취양%요추간반돌출증%Meta분석%수궤대조시험
ablation techniques%ozone%intervertebral disk displacement%lumbar vertebrae%meta-analysis
背景：靶点射频热凝联合臭氧为治疗腰椎间盘突出症提出了新思路，两者联合介入微创治疗能发挥各自优势，但其疗效尚缺乏循证医学证据支持。
<br> 目的：评价射频热凝靶点消融联合臭氧治疗腰椎间盘突出症的有效性和可行性。
<br> 方法：计算机检索PubMed、CENTRAL、SCI、EMBASE.com、中国生物医学文献数据库、万方数据库、中国期刊全文数据库等，检索时限均从建库开始至2013年6月22日。严格根据纳入排除标准，收集射频热凝术联合臭氧治疗腰椎间盘突出症的随机对照试验，依据Cochrane Handbook 5.1.0偏倚风险评估工具评价纳入研究质量，采用RevMan 5.2软件进行Meta分析。
<br> 结果与结论：数据库检索获得63条记录，最终纳入8个随机对照试验，662例患者。Meta分析结果显示：与单独臭氧组比较，射频热凝联合臭氧治疗后1周、3个月、6个月的优良率[RR=0.36，95%CI(0.21，0.59)；RR=0.24，95%CI(0.14，0.43)；RR=0.41，95%CI(0.24，0.70)]、有效率[RR=0.31，95%CI(0.12，0.82)；RR=0.28,95%CI(0.09，0.84)；RR=0.22，95%CI(0.06，0.80)]、目测类比评分[MD=-1.06，95%CI(-1.83，-0.28)]差异有显著性意义。结果可见，应用射频热凝联合臭氧注射治疗后腰椎间盘突出症患者疼痛缓解程度高，见效快，远期疗效好，安全可行。
揹景：靶點射頻熱凝聯閤臭氧為治療腰椎間盤突齣癥提齣瞭新思路，兩者聯閤介入微創治療能髮揮各自優勢，但其療效尚缺乏循證醫學證據支持。
<br> 目的：評價射頻熱凝靶點消融聯閤臭氧治療腰椎間盤突齣癥的有效性和可行性。
<br> 方法：計算機檢索PubMed、CENTRAL、SCI、EMBASE.com、中國生物醫學文獻數據庫、萬方數據庫、中國期刊全文數據庫等，檢索時限均從建庫開始至2013年6月22日。嚴格根據納入排除標準，收集射頻熱凝術聯閤臭氧治療腰椎間盤突齣癥的隨機對照試驗，依據Cochrane Handbook 5.1.0偏倚風險評估工具評價納入研究質量，採用RevMan 5.2軟件進行Meta分析。
<br> 結果與結論：數據庫檢索穫得63條記錄，最終納入8箇隨機對照試驗，662例患者。Meta分析結果顯示：與單獨臭氧組比較，射頻熱凝聯閤臭氧治療後1週、3箇月、6箇月的優良率[RR=0.36，95%CI(0.21，0.59)；RR=0.24，95%CI(0.14，0.43)；RR=0.41，95%CI(0.24，0.70)]、有效率[RR=0.31，95%CI(0.12，0.82)；RR=0.28,95%CI(0.09，0.84)；RR=0.22，95%CI(0.06，0.80)]、目測類比評分[MD=-1.06，95%CI(-1.83，-0.28)]差異有顯著性意義。結果可見，應用射頻熱凝聯閤臭氧註射治療後腰椎間盤突齣癥患者疼痛緩解程度高，見效快，遠期療效好，安全可行。
배경：파점사빈열응연합취양위치료요추간반돌출증제출료신사로，량자연합개입미창치료능발휘각자우세，단기료효상결핍순증의학증거지지。
<br> 목적：평개사빈열응파점소융연합취양치료요추간반돌출증적유효성화가행성。
<br> 방법：계산궤검색PubMed、CENTRAL、SCI、EMBASE.com、중국생물의학문헌수거고、만방수거고、중국기간전문수거고등，검색시한균종건고개시지2013년6월22일。엄격근거납입배제표준，수집사빈열응술연합취양치료요추간반돌출증적수궤대조시험，의거Cochrane Handbook 5.1.0편의풍험평고공구평개납입연구질량，채용RevMan 5.2연건진행Meta분석。
<br> 결과여결론：수거고검색획득63조기록，최종납입8개수궤대조시험，662례환자。Meta분석결과현시：여단독취양조비교，사빈열응연합취양치료후1주、3개월、6개월적우량솔[RR=0.36，95%CI(0.21，0.59)；RR=0.24，95%CI(0.14，0.43)；RR=0.41，95%CI(0.24，0.70)]、유효솔[RR=0.31，95%CI(0.12，0.82)；RR=0.28,95%CI(0.09，0.84)；RR=0.22，95%CI(0.06，0.80)]、목측류비평분[MD=-1.06，95%CI(-1.83，-0.28)]차이유현저성의의。결과가견，응용사빈열응연합취양주사치료후요추간반돌출증환자동통완해정도고，견효쾌，원기료효호，안전가행。
BACKGROUND:Support radiofrequency ablation combined with ozone provides novel idea for lumbar disc herniation. Their combination intervened with minimal y invasive surgery can bring their advantages, but its therapeutic effect stil lacks of evidences from evidence-based medicine.
<br> OBJECTIVE:To evaluate the effectiveness and feasibility of radiofrequency ablation combined with ozone for lumbar disc herniation.
<br> METHODS:Systematic and comprehensive database search was performed in PubMed, CENTRAL, SCI, EMBASE.com, Chinese Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang database for literatures published from database establishment to June 22 2013. According to inclusion and exclusion criteria, randomized control ed trials on support radiofrequency ablation combined with ozone for lumbar disc herniation were col ected. The risk of bias tool described in the Cochrane Handbook version 5.1.0 was used to assess the quality of each trial. Meta-analysis was performed using RevMan 5.2 software.
<br> RESULTS AND CONCLUSION:Total y 63 records were col ected. A total of 8 randomized control ed trials involving 662 patients met inclusion criteria. The results of meta-analysis showed between ozone alone, and at 1 week, 3 and 6 months after combined treatment, significant differences were detected in excellent and good rate [RR=0.36, 95%CI(0.21, 0.59);RR=0.24, 95%CI(0.14, 0.43);RR=0.41, 95%CI(0.24, 0.70)], effective rate [RR=0.31, 95%CI(0.12, 0.82);RR=0.28, 95%CI(0.09, 0.84);RR=0.22, 95%CI(0.06, 0.80)], and visual analogue scale score [MD=-1.06, 95%CI(-1.83,-0.28)]. Results indicated that radiofrequency ablation combined with ozone is effective and feasible for lumbar disc herniation, with the characteristics of fast recovery, pain relief, and good long-period therapeutic effects.
