中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
13期
2071-2076
,共6页
张鹏%王亭%曲邵政%张金锋%李书忠
張鵬%王亭%麯邵政%張金鋒%李書忠
장붕%왕정%곡소정%장금봉%리서충
植入物%脊柱植入物%神经鞘瘤%椎管内%椎间孔%钉棒系统%内固定%脊柱稳定性
植入物%脊柱植入物%神經鞘瘤%椎管內%椎間孔%釘棒繫統%內固定%脊柱穩定性
식입물%척주식입물%신경초류%추관내%추간공%정봉계통%내고정%척주은정성
neurilemmoma%lumbar vertebrae%internal fixators
文章的特点为:1对椎管内神经鞘瘤,作者采用了椎板切除双侧钉棒内固定,对椎间孔区域神经鞘瘤采用部分椎板关节突切除单侧钉棒内固定充分暴露肿瘤所在区域的视野,完整切除神经鞘瘤,有效避免损伤脊髓神经,更能有效维持脊柱稳定性,防止出现椎体滑脱、椎体失稳,可预期和重点观察远期效果。<br> 2对载瘤神经根的处理:椎管内外神经鞘瘤(尤其颈椎及下腰椎),切除椎管外神经根后往往造成相应支配区域的严重感觉、运动功能障碍。此神经鞘瘤,应予以尽量保留。<br> 3对脑脊液漏的处理:对于出现脑脊液漏合并感染者,不论年龄、体质好坏,均应立即行清创置管冲洗引流并根据药敏结果给予抗感染治疗。<br> 背景:神经鞘瘤切除方式的选择关系着瘤体能否切净、能否有效避免肿瘤切除过程中牵拉损伤脊髓神经,最终关系着治疗的预后。<br> 目的:分析椎管内、椎间孔区域神经鞘瘤行椎板关节突切除复合单侧或双侧钉棒系统置入内固定后的脊柱稳定性。<br> 方法:对颈、胸、腰不同部位椎管内、椎间孔区神经鞘瘤48例患者行椎板关节突切除复合钉棒系统置入内固定治疗,其中管内神经鞘瘤34例行双侧螺钉固定,椎间孔区域神经鞘瘤14例行单侧螺钉固定。<br> 结果与结论:内固定后3 d及内固定后3,6,12个月X射线复查结果示:内置物位置良好,植骨融合,无脊柱失稳、椎体滑脱现象。治疗后神经功能Bodford(1997)评分及生活质量评分均较治疗前显著提高(P<0.01);治疗后Lovett分级评估肌力较治疗前显著提高(P<0.01);治疗后疼痛程度分级(VRS)法疼痛较治疗前明显好转(P <0.01)。48例患者神经鞘瘤均完全切除,内固定后有6例出现脑脊液漏,1例出现脑脊液感染,有1例因脑脊液感染行二次手术,3例因肿瘤侵蚀神经根行肿瘤神经根一并切除。表明对椎管内神经鞘瘤采用椎板切除双侧钉棒内固定、椎间孔区域神经鞘瘤采用部分椎板关节突切除单侧钉棒能够充分暴露肿瘤所在区域的视野,完整切除神经鞘瘤,有效避免损伤脊髓神经,更能有效维持脊柱稳定性,防止出现椎体滑脱、椎体失稳,其远期效果尚需进一步研究。
文章的特點為:1對椎管內神經鞘瘤,作者採用瞭椎闆切除雙側釘棒內固定,對椎間孔區域神經鞘瘤採用部分椎闆關節突切除單側釘棒內固定充分暴露腫瘤所在區域的視野,完整切除神經鞘瘤,有效避免損傷脊髓神經,更能有效維持脊柱穩定性,防止齣現椎體滑脫、椎體失穩,可預期和重點觀察遠期效果。<br> 2對載瘤神經根的處理:椎管內外神經鞘瘤(尤其頸椎及下腰椎),切除椎管外神經根後往往造成相應支配區域的嚴重感覺、運動功能障礙。此神經鞘瘤,應予以儘量保留。<br> 3對腦脊液漏的處理:對于齣現腦脊液漏閤併感染者,不論年齡、體質好壞,均應立即行清創置管遲洗引流併根據藥敏結果給予抗感染治療。<br> 揹景:神經鞘瘤切除方式的選擇關繫著瘤體能否切淨、能否有效避免腫瘤切除過程中牽拉損傷脊髓神經,最終關繫著治療的預後。<br> 目的:分析椎管內、椎間孔區域神經鞘瘤行椎闆關節突切除複閤單側或雙側釘棒繫統置入內固定後的脊柱穩定性。<br> 方法:對頸、胸、腰不同部位椎管內、椎間孔區神經鞘瘤48例患者行椎闆關節突切除複閤釘棒繫統置入內固定治療,其中管內神經鞘瘤34例行雙側螺釘固定,椎間孔區域神經鞘瘤14例行單側螺釘固定。<br> 結果與結論:內固定後3 d及內固定後3,6,12箇月X射線複查結果示:內置物位置良好,植骨融閤,無脊柱失穩、椎體滑脫現象。治療後神經功能Bodford(1997)評分及生活質量評分均較治療前顯著提高(P<0.01);治療後Lovett分級評估肌力較治療前顯著提高(P<0.01);治療後疼痛程度分級(VRS)法疼痛較治療前明顯好轉(P <0.01)。48例患者神經鞘瘤均完全切除,內固定後有6例齣現腦脊液漏,1例齣現腦脊液感染,有1例因腦脊液感染行二次手術,3例因腫瘤侵蝕神經根行腫瘤神經根一併切除。錶明對椎管內神經鞘瘤採用椎闆切除雙側釘棒內固定、椎間孔區域神經鞘瘤採用部分椎闆關節突切除單側釘棒能夠充分暴露腫瘤所在區域的視野,完整切除神經鞘瘤,有效避免損傷脊髓神經,更能有效維持脊柱穩定性,防止齣現椎體滑脫、椎體失穩,其遠期效果尚需進一步研究。
문장적특점위:1대추관내신경초류,작자채용료추판절제쌍측정봉내고정,대추간공구역신경초류채용부분추판관절돌절제단측정봉내고정충분폭로종류소재구역적시야,완정절제신경초류,유효피면손상척수신경,경능유효유지척주은정성,방지출현추체활탈、추체실은,가예기화중점관찰원기효과。<br> 2대재류신경근적처리:추관내외신경초류(우기경추급하요추),절제추관외신경근후왕왕조성상응지배구역적엄중감각、운동공능장애。차신경초류,응여이진량보류。<br> 3대뇌척액루적처리:대우출현뇌척액루합병감염자,불론년령、체질호배,균응립즉행청창치관충세인류병근거약민결과급여항감염치료。<br> 배경:신경초류절제방식적선택관계착류체능부절정、능부유효피면종류절제과정중견랍손상척수신경,최종관계착치료적예후。<br> 목적:분석추관내、추간공구역신경초류행추판관절돌절제복합단측혹쌍측정봉계통치입내고정후적척주은정성。<br> 방법:대경、흉、요불동부위추관내、추간공구신경초류48례환자행추판관절돌절제복합정봉계통치입내고정치료,기중관내신경초류34례행쌍측라정고정,추간공구역신경초류14례행단측라정고정。<br> 결과여결론:내고정후3 d급내고정후3,6,12개월X사선복사결과시:내치물위치량호,식골융합,무척주실은、추체활탈현상。치료후신경공능Bodford(1997)평분급생활질량평분균교치료전현저제고(P<0.01);치료후Lovett분급평고기력교치료전현저제고(P<0.01);치료후동통정도분급(VRS)법동통교치료전명현호전(P <0.01)。48례환자신경초류균완전절제,내고정후유6례출현뇌척액루,1례출현뇌척액감염,유1례인뇌척액감염행이차수술,3례인종류침식신경근행종류신경근일병절제。표명대추관내신경초류채용추판절제쌍측정봉내고정、추간공구역신경초류채용부분추판관절돌절제단측정봉능구충분폭로종류소재구역적시야,완정절제신경초류,유효피면손상척수신경,경능유효유지척주은정성,방지출현추체활탈、추체실은,기원기효과상수진일보연구。
BACKGROUND:The choice of schwannoma resection is strongly associated with whether the tumor was completely resected, whether stretch during resection injures spinal nerves, and final y with the prognosis of treatment. <br> OBJECTIVE:To evaluate the spinal stabilization after laminectomy combining unilateral or bilateral nail-rod system for schwannoma in the spinal canal or intervertebral foramen. <br> METHODS:A total of 48 cases of schwannoma in the spinal canal or intervertebral foramen of neck, chest and waist underwent laminectomy combining unilateral or bilateral nail-rod system. 34 cases in spinal canal received bilateral nail-rod system, and 14 cases in the intervertebral foramen received unilateral nail-rod system. <br> RESULTS AND CONCLUSION:At 3 days and 3, 6, 12 months after internal fixation, radiograph results demonstrated that location of implants was good. Bone graft fusion was found. No spinal instability and vertebral slippage occurred. Neural functional score Bodford (1997) and quality of life score were significantly increased after treatment (P<0.01). Muscle strength assessed by Lovett grade was significantly elevated after treatment (P<0.01). Pain evaluated by Virtual Rescan grade was significantly lessened after treatment (P<0.01). Schwannoma was completely resected in 48 patients. After treatment, six patients affected leakage of cerebrospinal fluid. One case experienced infection of cerebrospinal fluid. One case had to undergo secondary operation due to the infection. Three cases received nerve root resection due to tumor erosion. These experimental results confirmed that laminectomy combining unilateral or bilateral nail-rod system for schwannoma in the spinal canal or intervertebral foramen has the advantage of the tumor ful y exposed to the operator, which can help completely resect schwannoma and effectively avoid spinal nerve injury. Even more important thing is that the spinal stability is reconstructed by unilateral or bilateral nail-rod system, which prevents the occurrence of vertebral slippage and vertebral destabilization. Long-term effect stil needs further research.